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Article

Increased Red Blood Cell Distribution Width in the First Year after Diagnosis Predicts Worsening of Systemic Sclerosis-Associated Interstitial Lung Disease at 5 Years: A Pilot Study

by
Satoshi Ebata
1,
Ayumi Yoshizaki
1,*,
Takemichi Fukasawa
1,
Asako Yoshizaki-Ogawa
1,
Yoshihide Asano
1,
Kosuke Kashiwabara
2,
Koji Oba
3 and
Shinichi Sato
1
1
Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
2
Clinical Research Support Center, The Tokyo University Hospital, Tokyo 113-8655, Japan
3
Department of Biostatistics, School of Public Health, Graduate School of Medicine, and Interfaculty Initiative in Information Studies, The University of Tokyo, Tokyo 113-0033, Japan
*
Author to whom correspondence should be addressed.
Diagnostics 2021, 11(12), 2274; https://doi.org/10.3390/diagnostics11122274
Submission received: 25 October 2021 / Revised: 29 November 2021 / Accepted: 1 December 2021 / Published: 4 December 2021
(This article belongs to the Special Issue Advances in Identification and Management of Systemic Sclerosis)
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Abstract

The course of systemic sclerosis-associated interstitial lung disease (SSc-ILD) varies among individuals. Red blood cell distribution width (RDW) has been reported to be a predictor of idiopathic pulmonary fibrosis. However, there are no studies on the relationship between RDW and SSc-ILD. We conducted a retrospective study of 28 patients who were diagnosed with SSc-ILD on their first visit to our hospital and were followed-up for 5 years. The correlation between the changes in RDW, KL-6, and SP-D (ΔRDW, ΔKL-6, ΔSP-D) and the changes in percent-predicted forced lung volume and % carbon monoxide diffusion (Δ%FVC, Δ%DLco) was investigated. ΔRDW at 1 year after diagnosis was significantly inversely correlated with Δ%FVC at 5 years after diagnosis (r = −0.51, p < 0.001) and Δ%DLco at 5 years after diagnosis (r = −0.47, p < 0.001), whereas ΔKL-6 and ΔSP-D at 1 year were not correlated with Δ%FVC or Δ%DLco at 5 years. In the group of SSc-ILD patients with RDW increase in the first year after diagnosis, %FVC and %DLco were significantly lower than baseline at 3-, 4-, and 5-year assessments. In the group of patients without RDW increase in the first year, %FVC and %DLco did not decrease during the follow-up period. In conclusion, the changes in RDW in the first year after diagnosis may be useful surrogate markers to predict the long-term course of SSc-ILD.
Keywords: forced vital capacity; peripheral blood marker; red blood cell distribution width; systemic sclerosis; systemic sclerosis-associated interstitial lung disease forced vital capacity; peripheral blood marker; red blood cell distribution width; systemic sclerosis; systemic sclerosis-associated interstitial lung disease

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MDPI and ACS Style

Ebata, S.; Yoshizaki, A.; Fukasawa, T.; Yoshizaki-Ogawa, A.; Asano, Y.; Kashiwabara, K.; Oba, K.; Sato, S. Increased Red Blood Cell Distribution Width in the First Year after Diagnosis Predicts Worsening of Systemic Sclerosis-Associated Interstitial Lung Disease at 5 Years: A Pilot Study. Diagnostics 2021, 11, 2274. https://doi.org/10.3390/diagnostics11122274

AMA Style

Ebata S, Yoshizaki A, Fukasawa T, Yoshizaki-Ogawa A, Asano Y, Kashiwabara K, Oba K, Sato S. Increased Red Blood Cell Distribution Width in the First Year after Diagnosis Predicts Worsening of Systemic Sclerosis-Associated Interstitial Lung Disease at 5 Years: A Pilot Study. Diagnostics. 2021; 11(12):2274. https://doi.org/10.3390/diagnostics11122274

Chicago/Turabian Style

Ebata, Satoshi, Ayumi Yoshizaki, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Yoshihide Asano, Kosuke Kashiwabara, Koji Oba, and Shinichi Sato. 2021. "Increased Red Blood Cell Distribution Width in the First Year after Diagnosis Predicts Worsening of Systemic Sclerosis-Associated Interstitial Lung Disease at 5 Years: A Pilot Study" Diagnostics 11, no. 12: 2274. https://doi.org/10.3390/diagnostics11122274

APA Style

Ebata, S., Yoshizaki, A., Fukasawa, T., Yoshizaki-Ogawa, A., Asano, Y., Kashiwabara, K., Oba, K., & Sato, S. (2021). Increased Red Blood Cell Distribution Width in the First Year after Diagnosis Predicts Worsening of Systemic Sclerosis-Associated Interstitial Lung Disease at 5 Years: A Pilot Study. Diagnostics, 11(12), 2274. https://doi.org/10.3390/diagnostics11122274

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