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Article

Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome

1
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Aleutskaya str., 4, 634014 Tomsk, Russia
2
University Hospital, Siberian State Medical University, Moskovsky trakt, 2, 634050 Tomsk, Russia
3
Department of Fundamental Psychology and Behavioral Medicine, Siberian State Medical University, Moskovsky trakt, 2, 634050 Tomsk, Russia
4
Department of Medical and Biological Cybernetics, Siberian State Medical University, Moskovsky trakt, 2, 634050 Tomsk, Russia
5
PharmacoTherapy, -Epidemiology and -Economics, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands
6
Department of Psychiatry, Addictology and Psychotherapy, Siberian State Medical University, Moskovsky trakt, 2, 634050 Tomsk, Russia
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(9), 683; https://doi.org/10.3390/diagnostics10090683
Received: 21 August 2020 / Revised: 6 September 2020 / Accepted: 8 September 2020 / Published: 10 September 2020
In this study, we aim to investigate associations between body fat parameters, glucose and lipid profiles, thyroid-stimulating hormone (TSH), and thyroid hormones (THs) levels in Tomsk-region schizophrenia patients depending upon the presence or absence of metabolic syndrome (MetS). A total of 156 psychiatric inpatients with schizophrenia who had been treated with antipsychotics for at least six months before entry were studied: 56 with and 100 without MetS. Reference groups consisted of general hospital inpatients with MetS and without schizophrenia (n = 35) and healthy individuals (n = 35). Statistical analyses were performed using the Mann–Whitney U-test, chi-square test, Spearman’s rank correlation coefficient, multiple regression analyses, and descriptive statistics. Patients with schizophrenia and MetS had significantly higher levels of free triiodothyronine (FT3) and thyroxine (FT4) compared to schizophrenia patients without MetS (3.68 [3.25; 5.50] vs. 3.24 [2.81; 3.66], p = 0.0001, and 12.68 [10.73; 15.54] vs. 10.81 [9.76; 12.3], p = 0.0001, in pmol/L, respectively). FT3 maintained an association with MetS (p = 0.0001), sex (p = 0.0001), age (p = 0.022), and high-density lipoproteins (p = 0.033). FT4 maintained an association with MetS (p = 0.0001), sex (p = 0.001), age (p = 0.014), and glucose (p = 0.009). The data obtained showed body fat parameters, glucose and lipid profiles, and THs levels in Western-Siberian schizophrenia patients depending on MetS presence or absence. View Full-Text
Keywords: schizophrenia; metabolic syndrome; visceral fat; thyroid hormone; biochemical parameters; antipsychotics schizophrenia; metabolic syndrome; visceral fat; thyroid hormone; biochemical parameters; antipsychotics
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MDPI and ACS Style

Kornetova, E.G.; Kornetov, A.N.; Mednova, I.A.; Lobacheva, O.A.; Gerasimova, V.I.; Dubrovskaya, V.V.; Tolmachev, I.V.; Semke, A.V.; Loonen, A.J.M.; Bokhan, N.A.; Ivanova, S.A. Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome. Diagnostics 2020, 10, 683. https://doi.org/10.3390/diagnostics10090683

AMA Style

Kornetova EG, Kornetov AN, Mednova IA, Lobacheva OA, Gerasimova VI, Dubrovskaya VV, Tolmachev IV, Semke AV, Loonen AJM, Bokhan NA, Ivanova SA. Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome. Diagnostics. 2020; 10(9):683. https://doi.org/10.3390/diagnostics10090683

Chicago/Turabian Style

Kornetova, Elena G., Alexander N. Kornetov, Irina A. Mednova, Olga A. Lobacheva, Valeria I. Gerasimova, Viktoria V. Dubrovskaya, Ivan V. Tolmachev, Arkadiy V. Semke, Anton J.M. Loonen, Nikolay A. Bokhan, and Svetlana A. Ivanova 2020. "Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome" Diagnostics 10, no. 9: 683. https://doi.org/10.3390/diagnostics10090683

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