Next Article in Journal
Prognostic Value of Ki67 Percentage, WT-1 Expression and p16/CDKN2A Deletion in Diffuse Malignant Peritoneal Mesothelioma: A Single-Centre Cohort Study
Next Article in Special Issue
Brain Metastases Unresponsive to Immunotherapy Detected by 18F-FDG-PET/CT in a Patient with Melanoma
Previous Article in Journal
“Noninfective Endocarditis”: A Case Report of Hereditary Coagulation Disorders in a 28-Year-Old Male
Previous Article in Special Issue
Diagnosis of Dizziness Due to a Core Vestibular Projection Injury in a Patient with Intracerebral Hemorrhage
Open AccessInteresting Images

Dural Metastases of Advanced Prostate Cancer Detected by 18F-Fluorocholine

1
Division of Radiology, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy
2
Division of Nuclear Medicine, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy
3
Department of Medical Oncology, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(6), 385; https://doi.org/10.3390/diagnostics10060385
Received: 14 May 2020 / Revised: 4 June 2020 / Accepted: 5 June 2020 / Published: 8 June 2020
(This article belongs to the Collection Interesting Images)
Prostate cancer with extensive dural metastases is very rare, with only few cases described in the literature. We report one such case of a 74-year-old man with advanced prostate cancer, and in relatively good clinical condition. The patient returned with complaints of headache and diplopia. Fluorocholine (18F) chloride (18F-FCH) is an analog of choline in which a hydrogen atom has been replaced by fluorine (18F). After crossing the cell membrane by a carrier-mediated mechanism, choline is phosphorylated by choline kinase to produce phosphorylcholine. 18F-FCH positron emission tomography–computed tomography (PET/CT) is widely used to stage and restage patients affected by prostate cancer with good sensitivity. 18F-FCH PET/CT showed disease progression with the onset of multiple skull lesions. Numerous suspicious dural hypermetabolic lesions indicating neoplastic involvement were detected along the fronto-parietal convexities, in the left fronto-orbital region and right lateral wall of the orbit, concerning for metastases in these regions. A contrast-enhanced computed tomography (CECT) scan was performed which showed corresponding enhancing tissue which correlated with the PET findings. The final imaging diagnosis was osteo-dural metastases from prostate cancer associated with poor outcome. Awareness of this pattern of metastases may be of clinical relevance in order to avoid unnecessary invasive diagnostic procedures in groups of patients with a dismal prognosis. View Full-Text
Keywords: 18F-fluorocholine; prostate cancer; computed tomography; dural metastases; subdural hematomas 18F-fluorocholine; prostate cancer; computed tomography; dural metastases; subdural hematomas
Show Figures

Figure 1

MDPI and ACS Style

Morassi, M.; Bonacina, M.; Bnà, C.; Zaniboni, A.; Savelli, G. Dural Metastases of Advanced Prostate Cancer Detected by 18F-Fluorocholine. Diagnostics 2020, 10, 385.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop