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Open AccessArticle

Prognostic Value of Ki67 Percentage, WT-1 Expression and p16/CDKN2A Deletion in Diffuse Malignant Peritoneal Mesothelioma: A Single-Centre Cohort Study

1
Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy
2
Pathology Division, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy
3
Pathology Division, IRCCS National Cancer Institute “Giovanni Paolo II”, 70124 Bari, Italy
4
Occupational Health Division, Department of Interdisciplinary Medicine, University of Bari, 70124 Bari, Italy
5
Pathology Division, Department of Surgery, University of Foggia, 71122 Foggia, Italy
*
Authors to whom correspondence should be addressed.
Diagnostics 2020, 10(6), 386; https://doi.org/10.3390/diagnostics10060386
Received: 12 May 2020 / Revised: 3 June 2020 / Accepted: 5 June 2020 / Published: 9 June 2020
(This article belongs to the Section Pathology and Molecular Diagnostics)
Diffuse malignant peritoneal mesothelioma (DMPM) is a rare malignant neoplasm with a poor survival. Although some advances in knowledge have been obtained for the pleural form, much less is known about DMPM. Advantages in terms of prognosis are still limited and strong efforts need to be made. The aim of our study was to correlate several histological and molecular factors with survival in a large cohort of 45 DMPMs. We evaluated histotype, nuclear grade, mitotic count, necrosis, inflammation, desmoplastic reaction, Ki67 percentage, WT-1 expression, p16 protein by immunohistochemistry and CDKN2A deletion by FISH. Our results showed that epithelioid histotype, nuclear grade 2, mitotic count ≤5 x mm2, absence of desmoplasia and p16/CDKN2A deletion, low Ki67 value, and high WT-1 expression were correlated with the most prolonged survival (p = 0.0001). Moreover, p16 loss in immunohistochemistry reflected CDKN2A deletion detected with FISH, and both were correlated with the worst survival (p = 0.0001). At multivariate analysis, Ki67 value, WT-1 expression and p16/CDKN2A deletion emerged as independent prognostic factors (p = 0.01, p = 0.0001 and p = 0.01, respectively). These parameters are easy to analyse at the time of DMPM diagnosis and may support better patient stratification, prediction of treatment effectiveness and therapeutic optimization. View Full-Text
Keywords: diffuse malignant peritoneal mesothelioma; prognostic factors; Ki67; WT-1; p16; CDKN2A diffuse malignant peritoneal mesothelioma; prognostic factors; Ki67; WT-1; p16; CDKN2A
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Pezzuto, F.; Serio, G.; Fortarezza, F.; Scattone, A.; Caporusso, C.; Punzi, A.; Cavone, D.; Pennella, A.; Marzullo, A.; Vimercati, L. Prognostic Value of Ki67 Percentage, WT-1 Expression and p16/CDKN2A Deletion in Diffuse Malignant Peritoneal Mesothelioma: A Single-Centre Cohort Study. Diagnostics 2020, 10, 386.

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