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Open AccessArticle

Regulation of Genes Involved in Heterocyst Differentiation in the Cyanobacterium Anabaena sp. Strain PCC 7120 by a Group 2 Sigma Factor SigC

by Shigeki Ehira 1,2,* and Shogo Miyazaki 1
1
Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, Hachioji, Tokyo 192-0397, Japan
2
Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: John C. Meeks and Robert Haselkorn
Life 2015, 5(1), 587-603; https://doi.org/10.3390/life5010587
Received: 23 December 2014 / Revised: 6 February 2015 / Accepted: 11 February 2015 / Published: 16 February 2015
(This article belongs to the Special Issue Cyanobacteria: Ecology, Physiology and Genetics)
The filamentous cyanobacterium Anabaena sp. strain PCC 7120 differentiates specialized cells for nitrogen fixation called heterocysts upon limitation of combined nitrogen in the medium. During heterocyst differentiation, expression of approximately 500 genes is upregulated with spatiotemporal regulation. In the present study, we investigated the functions of sigma factors of RNA polymerase in the regulation of heterocyst differentiation. The transcript levels of sigC, sigE, and sigG were increased during heterocyst differentiation, while expression of sigJ was downregulated. We carried out DNA microarray analysis to identify genes regulated by SigC, SigE, and SigG. It was indicated that SigC regulated the expression of genes involved in heterocyst differentiation and functions. Moreover, genes regulated by SigC partially overlapped with those regulated by SigE, and deficiency of SigC was likely to be compensated by SigE. View Full-Text
Keywords: sigma factor; transcriptional regulation; heterocyst differentiation; Anabaena sigma factor; transcriptional regulation; heterocyst differentiation; Anabaena
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Ehira, S.; Miyazaki, S. Regulation of Genes Involved in Heterocyst Differentiation in the Cyanobacterium Anabaena sp. Strain PCC 7120 by a Group 2 Sigma Factor SigC. Life 2015, 5, 587-603.

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