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Volume 13
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10.3390/life13040926
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Opinion

An Overview of the Putative Structural and Functional Properties of the GHBh1 Receptor through a Bioinformatics Approach

by
Casper J. H. Wolf
1,2,3,*,
Hanka Venselaar
4,
Marcia Spoelder
5,
Harmen Beurmanjer
3,6,7,
Arnt F. A. Schellekens
1,3,† and
Judith R. Homberg
2,†
1
Department of Psychiatry, Radboudumc, 6525 GC Nijmegen, The Netherlands
2
Department of Cognitive Neuroscience, Donders Institute for Brain Cognition and Behaviour, Radboudumc, 6525 EN Nijmegen, The Netherlands
3
Nijmegen Institute for Scientist-Practitioners in Addiction (NISPA), 6525 HR Nijmegen, The Netherlands
4
Center for Molecular and Biomolecular Informatics, Radboudumc, 6525 GA Nijmegen, The Netherlands
5
Department of Primary and Community Care, Radboudumc, 6525 GC Nijmegen, The Netherlands
6
Behavioural Science Institute, Radboud University, 6525 GD Nijmegen, The Netherlands
7
Novadic-Kentron Addiction Care, 5261 LX Vught, The Netherlands
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Life 2023, 13(4), 926; https://doi.org/10.3390/life13040926
Submission received: 27 February 2023 / Revised: 24 March 2023 / Accepted: 30 March 2023 / Published: 31 March 2023
(This article belongs to the Special Issue What Is New in Psychiatry and Psychopharmacology?)
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Abstract

The neurotransmitter γ-hydroxybutyric acid (GHB) is suggested to be involved in neuronal energy homeostasis processes, but the substance is also used as a recreational drug and as a prescription medication for narcolepsy. GHB has several high-affinity targets in the brain, commonly generalized as the GHB receptor. However, little is known about the structural and functional properties of GHB receptor subtypes. This opinion article discusses the literature on the putative structural and functional properties of the GHBh1 receptor subtype. GHBh1 contains 11 transmembrane helices and at least one intracellular intrinsically disordered region (IDR). Additionally, GHBh1 shows a 100% overlap in amino acid sequence with the Riboflavin (vitamin B2) transporter, which opens the possibility of a possible dual-function (transceptor) structure. Riboflavin and GHB also share specific neuroprotective properties. Further research into the GHBh1 receptor subtype may pave the way for future therapeutic possibilities for GHB.
Keywords: gamma-hydroxybutyric acid; GHB; drug addiction; riboflavin; receptor structure; receptor model gamma-hydroxybutyric acid; GHB; drug addiction; riboflavin; receptor structure; receptor model

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MDPI and ACS Style

Wolf, C.J.H.; Venselaar, H.; Spoelder, M.; Beurmanjer, H.; Schellekens, A.F.A.; Homberg, J.R. An Overview of the Putative Structural and Functional Properties of the GHBh1 Receptor through a Bioinformatics Approach. Life 2023, 13, 926. https://doi.org/10.3390/life13040926

AMA Style

Wolf CJH, Venselaar H, Spoelder M, Beurmanjer H, Schellekens AFA, Homberg JR. An Overview of the Putative Structural and Functional Properties of the GHBh1 Receptor through a Bioinformatics Approach. Life. 2023; 13(4):926. https://doi.org/10.3390/life13040926

Chicago/Turabian Style

Wolf, Casper J. H., Hanka Venselaar, Marcia Spoelder, Harmen Beurmanjer, Arnt F. A. Schellekens, and Judith R. Homberg. 2023. "An Overview of the Putative Structural and Functional Properties of the GHBh1 Receptor through a Bioinformatics Approach" Life 13, no. 4: 926. https://doi.org/10.3390/life13040926

APA Style

Wolf, C. J. H., Venselaar, H., Spoelder, M., Beurmanjer, H., Schellekens, A. F. A., & Homberg, J. R. (2023). An Overview of the Putative Structural and Functional Properties of the GHBh1 Receptor through a Bioinformatics Approach. Life, 13(4), 926. https://doi.org/10.3390/life13040926

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