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Article

Reduced Plasma Ascorbate and Increased Proportion of Dehydroascorbic Acid Levels in Patients Undergoing Hemodialysis

1
Molecular Regulation of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan
2
Department of Biological Sciences, Tokyo Metropolitan University, Tokyo 192-0397, Japan
3
Department of Nephrology, Tokyo Metropolitan Geriatric Hospital, Tokyo 173-0015, Japan
4
Department of Nephrology and Endocrinology, Tohoku Medical and Pharmaceutical University Hospital, Miyagi 983-8512, Japan
5
Saitama Central Hospital, Saitama 354-0045, Japan
*
Author to whom correspondence should be addressed.
Equal contribution.
Academic Editors: Jeanne A Drisko and Qi Chen
Life 2021, 11(10), 1023; https://doi.org/10.3390/life11101023
Received: 20 August 2021 / Revised: 24 September 2021 / Accepted: 25 September 2021 / Published: 28 September 2021
(This article belongs to the Special Issue Antimicrobial Mechanisms of Vitamin C)
Ascorbate functions as an electron donor and scavenges free radicals. Dehydroascorbic acid (DHA), the oxidized form of ascorbate, is generated as a result of these reactions. While low plasma ascorbate levels have been reported in hemodialysis patients worldwide, no studies have measured DHA because it is not generalized. In this study, we aimed to clarify whether plasma ascorbate levels are low in dialysis patients and whether plasma ascorbate levels fluctuate before and after dialysis. Moreover, we applied our previously established method to measure the plasma ascorbate and DHA levels in chronic kidney disease (CKD) stage G3–G5 non-hemodialysis-dependent patients, and pre- and post-dialysis plasma ascorbate and DHA levels in CKD stage G5D hemodialysis patients. The sample size was calculated using G-power software. The pre-dialysis plasma total ascorbate levels, including DHA, were significantly (56%) lower in hemodialysis patients than in non-hemodialysis-dependent CKD patients. After dialysis, there was a 40% reduction in the plasma total ascorbate levels. Hemodialysis increased the post-dialysis plasma proportions of DHA from 37% to 55%. The study results demonstrated lower plasma total ascorbate levels in hemodialysis patients compared with in non-hemodialysis-dependent CKD patients; these low levels in hemodialysis patients were further reduced by hemodialysis and increased DHA proportion. View Full-Text
Keywords: chronic kidney disease; hemodialysis; hyperkalemia; ascorbate; dehydroascorbic acid; vitamin C; potassium chronic kidney disease; hemodialysis; hyperkalemia; ascorbate; dehydroascorbic acid; vitamin C; potassium
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MDPI and ACS Style

Doshida, Y.; Itabashi, M.; Takei, T.; Takino, Y.; Sato, A.; Yumura, W.; Maruyama, N.; Ishigami, A. Reduced Plasma Ascorbate and Increased Proportion of Dehydroascorbic Acid Levels in Patients Undergoing Hemodialysis. Life 2021, 11, 1023. https://doi.org/10.3390/life11101023

AMA Style

Doshida Y, Itabashi M, Takei T, Takino Y, Sato A, Yumura W, Maruyama N, Ishigami A. Reduced Plasma Ascorbate and Increased Proportion of Dehydroascorbic Acid Levels in Patients Undergoing Hemodialysis. Life. 2021; 11(10):1023. https://doi.org/10.3390/life11101023

Chicago/Turabian Style

Doshida, Yuta, Mitsuyo Itabashi, Takashi Takei, Yuka Takino, Ayami Sato, Wako Yumura, Naoki Maruyama, and Akihito Ishigami. 2021. "Reduced Plasma Ascorbate and Increased Proportion of Dehydroascorbic Acid Levels in Patients Undergoing Hemodialysis" Life 11, no. 10: 1023. https://doi.org/10.3390/life11101023

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