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Organocatalytic Enantioselective Henry Reactions

1
Laboratory of Asymmetric Synthesis, Department of Organic Chemistry, Institute of Synthetic Chemistry and Homogeneous Catalysis (ISQCH), University of Zaragoza-CSIC, E-50009 Zaragoza, Spain
2
ARAID, Aragon I+D Foundation, E-50004 Zaragoza, Spain
*
Author to whom correspondence should be addressed.
Symmetry 2011, 3(2), 220-245; https://doi.org/10.3390/sym3020220
Received: 29 March 2011 / Revised: 10 May 2011 / Accepted: 11 May 2011 / Published: 23 May 2011
(This article belongs to the Special Issue Asymmetric Organocatalysis)
A large number of interesting organocatalytic enantioselective protocols have been explored and successfully applied in the last decade. Among them, the Henry (nitroaldol) reaction represents a powerful carbon-carbon bond-forming procedure for the preparation of valuable synthetic intermediates, such as enantioenriched nitro alcohols, which can be further transformed in a number of important nitrogen and oxygen-containing compounds. This area of research is still in expansion and a more complex version of this useful process has recently emerged, the domino Michael/Henry protocol, affording highly functionalized cycles with multiple stereogenic centers. View Full-Text
Keywords: Henry; nitroaldol; organocatalysis; enantioselective; nitroalkanes; domino Michael/Henry Henry; nitroaldol; organocatalysis; enantioselective; nitroalkanes; domino Michael/Henry
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Alvarez-Casao, Y.; Marques-Lopez, E.; Herrera, R.P. Organocatalytic Enantioselective Henry Reactions. Symmetry 2011, 3, 220-245.

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