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Keywords = domino Michael/Henry

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26 pages, 1519 KB  
Review
Organocatalytic Enantioselective Henry Reactions
by Yolanda Alvarez-Casao, Eugenia Marques-Lopez and Raquel P. Herrera
Symmetry 2011, 3(2), 220-245; https://doi.org/10.3390/sym3020220 - 23 May 2011
Cited by 124 | Viewed by 12886
Abstract
A large number of interesting organocatalytic enantioselective protocols have been explored and successfully applied in the last decade. Among them, the Henry (nitroaldol) reaction represents a powerful carbon-carbon bond-forming procedure for the preparation of valuable synthetic intermediates, such as enantioenriched nitro alcohols, which [...] Read more.
A large number of interesting organocatalytic enantioselective protocols have been explored and successfully applied in the last decade. Among them, the Henry (nitroaldol) reaction represents a powerful carbon-carbon bond-forming procedure for the preparation of valuable synthetic intermediates, such as enantioenriched nitro alcohols, which can be further transformed in a number of important nitrogen and oxygen-containing compounds. This area of research is still in expansion and a more complex version of this useful process has recently emerged, the domino Michael/Henry protocol, affording highly functionalized cycles with multiple stereogenic centers. Full article
(This article belongs to the Special Issue Asymmetric Organocatalysis)
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