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Genes, Volume 3, Issue 2

June 2012 - 7 articles

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Articles (7)

  • Review
  • Open Access
128 Citations
14,173 Views
24 Pages

The Role of Bromodomain Proteins in Regulating Gene Expression

  • Gabrielle A. Josling,
  • Shamista A. Selvarajah,
  • Michaela Petter and
  • Michael F. Duffy

29 May 2012

Histone modifications are important in regulating gene expression in eukaryotes. Of the numerous histone modifications which have been identified, acetylation is one of the best characterised and is generally associated with active genes. Histone ace...

  • Article
  • Open Access
8 Citations
9,215 Views
29 Pages

The Chlamydiales Pangenome Revisited: Structural Stability and Functional Coherence

  • Fotis E. Psomopoulos,
  • Victoria I. Siarkou,
  • Nikolas Papanikolaou,
  • Ioannis Iliopoulos,
  • Athanasios S. Tsaftaris,
  • Vasilis J. Promponas and
  • Christos A. Ouzounis

16 May 2012

The entire publicly available set of 37 genome sequences from the bacterial order Chlamydiales has been subjected to comparative analysis in order to reveal the salient features of this pangenome and its evolutionary history. Over 2,000 protein famil...

  • Communication
  • Open Access
4 Citations
10,717 Views
13 Pages

The Chernobyl Tissue Bank — A Repository for Biomaterial and Data Used in Integrative and Systems Biology Modeling the Human Response to Radiation

  • Geraldine Thomas,
  • Kristian Unger,
  • Marko Krznaric,
  • Angela Galpine,
  • Jackie Bethel,
  • Christopher Tomlinson,
  • Mark Woodbridge and
  • Sarah Butcher

9 May 2012

The only unequivocal radiological effect of the Chernobyl accident on human health is the increase in thyroid cancer in those exposed in childhood or early adolescence. In response to the scientific interest in studying the molecular biology of thyro...

  • Communication
  • Open Access
120 Citations
13,254 Views
17 Pages

12 April 2012

Campylobacteriosis remains a major human public health problem world-wide. Genetic analyses of Campylobacter isolates, and particularly molecular epidemiology, have been central to the study of this disease, particularly the characterization of Campy...

  • Article
  • Open Access
6 Citations
7,545 Views
13 Pages

Heritability of Radiation Response in Lung Cancer Families

  • Albert Rosenberger,
  • Ute Rössler,
  • Sabine Hornhardt,
  • Wiebke Sauter,
  • Heike Bickeböller,
  • H.-Erich Wichmann and
  • Maria Gomolka

29 March 2012

Radiation sensitivity is assumed to be a cancer susceptibility factor due to impaired DNA damage signalling and repair. Relevant genetic factors may also determine the observed familial aggregation of early onset lung cancer. We investigated the heri...

  • Review
  • Open Access
55 Citations
12,317 Views
42 Pages

From Environment to Man: Genome Evolution and Adaptation of Human Opportunistic Bacterial Pathogens

  • Fabien Aujoulat,
  • Frédéric Roger,
  • Alice Bourdier,
  • Anne Lotthé,
  • Brigitte Lamy,
  • Hélène Marchandin and
  • Estelle Jumas-Bilak

26 March 2012

Environment is recognized as a huge reservoir for bacterial species and a source of human pathogens. Some environmental bacteria have an extraordinary range of activities that include promotion of plant growth or disease, breakdown of pollutants, pro...

  • Article
  • Open Access
7 Citations
11,352 Views
15 Pages

26 March 2012

Chicken developmental mutants are valuable for discovering sequences and pathways controlling amniote development. Herein we applied the advanced technologies of targeted sequence genomic capture enrichment and next-generation sequencing to discover...

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Genes - ISSN 2073-4425