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Volume 13
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10.3390/genes13030416
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Article

Liver Transcriptome Response to Heat Stress in Beijing You Chickens and Guang Ming Broilers

by
Astrid Lissette Barreto Sánchez
†,
Qiao Wang
†,
Mamadou Thiam
,
Zixuan Wang
,
Jin Zhang
,
Qi Zhang
,
Na Zhang
,
Qinghe Li
,
Jie Wen
and
Guiping Zhao
*
State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Genes 2022, 13(3), 416; https://doi.org/10.3390/genes13030416
Submission received: 10 January 2022 / Revised: 12 February 2022 / Accepted: 13 February 2022 / Published: 25 February 2022
(This article belongs to the Special Issue Advances in Poultry Genetics and Genomics)
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Abstract

Heat stress is one of the most prevalent issues in poultry production that reduces performance, robustness, and economic gains. Previous studies have demonstrated that native chickens are more tolerant of heat than commercial breeds. However, the underlying mechanisms of the heat tolerance observed in native chicken breeds remain unelucidated. Therefore, we performed a phenotypical, physiological, liver transcriptome comparative analysis and WGCNA in response to heat stress in one native (Beijing You, BY) and one commercial (Guang Ming, GM) chicken breed. The objective of this study was to evaluate the heat tolerance and identify the potential driver and hub genes related to heat stress in these two genetically distinct chicken breeds. In brief, 80 BY and 60 GM, 21 days old chickens were submitted to a heat stress experiment for 5 days (33 °C, 8 h/day). Each breed was divided into experimental groups of control (Ctl) and heat stress (HS). The results showed that BY chickens were less affected by heat stress and displayed reduced DEGs than GM chickens, 365 DEGs and 382 DEGs, respectively. The transcriptome analysis showed that BY chickens exhibited enriched pathways related to metabolism activity, meanwhile GM chickens’ pathways were related to inflammatory reactions. CPT1A and ANGPTL4 for BY chickens, and HSP90B1 and HSPA5 for GM chickens were identified as potential candidate genes associated with HS. The WGCNA revealed TLR7, AR, BAG3 genes as hub genes, which could play an important role in HS. The results generated in this study provide valuable resources for studying liver transcriptome in response to heat stress in native and commercial chicken lines.
Keywords: heat stress; Beijing You; Guang Ming; transcriptome; WGCNA heat stress; Beijing You; Guang Ming; transcriptome; WGCNA

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MDPI and ACS Style

Barreto Sánchez, A.L.; Wang, Q.; Thiam, M.; Wang, Z.; Zhang, J.; Zhang, Q.; Zhang, N.; Li, Q.; Wen, J.; Zhao, G. Liver Transcriptome Response to Heat Stress in Beijing You Chickens and Guang Ming Broilers. Genes 2022, 13, 416. https://doi.org/10.3390/genes13030416

AMA Style

Barreto Sánchez AL, Wang Q, Thiam M, Wang Z, Zhang J, Zhang Q, Zhang N, Li Q, Wen J, Zhao G. Liver Transcriptome Response to Heat Stress in Beijing You Chickens and Guang Ming Broilers. Genes. 2022; 13(3):416. https://doi.org/10.3390/genes13030416

Chicago/Turabian Style

Barreto Sánchez, Astrid Lissette, Qiao Wang, Mamadou Thiam, Zixuan Wang, Jin Zhang, Qi Zhang, Na Zhang, Qinghe Li, Jie Wen, and Guiping Zhao. 2022. "Liver Transcriptome Response to Heat Stress in Beijing You Chickens and Guang Ming Broilers" Genes 13, no. 3: 416. https://doi.org/10.3390/genes13030416

APA Style

Barreto Sánchez, A. L., Wang, Q., Thiam, M., Wang, Z., Zhang, J., Zhang, Q., Zhang, N., Li, Q., Wen, J., & Zhao, G. (2022). Liver Transcriptome Response to Heat Stress in Beijing You Chickens and Guang Ming Broilers. Genes, 13(3), 416. https://doi.org/10.3390/genes13030416

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