Next Article in Journal
Bioinformatic and Machine Learning Applications in Melanoma Risk Assessment and Prognosis: A Literature Review
Next Article in Special Issue
The Persistence of Staphylococcus aureus in Pressure Ulcers: A Colonising Role
Previous Article in Journal
Genomic Variation in Korean japonica Rice Varieties
Previous Article in Special Issue
Impact of Bicarbonate-β-Lactam Exposures on Methicillin-Resistant Staphylococcus aureus (MRSA) Gene Expression in Bicarbonate-β-Lactam-Responsive vs. Non-Responsive Strains
Review

The Staphylococcus aureus CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements

1
Genomic Research Laboratory, Service of Infectious Diseases, Faculty of Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland
2
Institut des Agents Infectieux, Centre de Biologie du Nord, Hospices Civils de Lyon, F-69003 Lyon, France
3
UFR de Chimie et de Biologie, Faculté des Sciences, Université Grenoble Alpes, 38000 Grenoble, France
4
Geneva Centre for Emerging Viral Diseases, Faculty of Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland
5
UMR 1282 Infectiologie Santé Publique, Université de Tours, F-37032 Tours, France
*
Author to whom correspondence should be addressed.
Academic Editor: Taeok Bae
Genes 2021, 12(11), 1752; https://doi.org/10.3390/genes12111752
Received: 29 September 2021 / Revised: 25 October 2021 / Accepted: 28 October 2021 / Published: 30 October 2021
(This article belongs to the Special Issue Genetics, Genomics and Pathogenesis of Staphylococcus aureus)
Among clinically relevant lineages of Staphylococcus aureus, the lineage or clonal complex 398 (CC398) is of particular interest. Strains from this lineage were only described as livestock colonizers until 2007. Progressively, cases of infection were reported in humans in contact with farm animals, and now, CC398 isolates are increasingly identified as the cause of severe infections even in patients without any contact with animals. These observations suggest that CC398 isolates have spread not only in the community but also in the hospital setting. In addition, several recent studies have reported that CC398 strains are evolving towards increased virulence and antibiotic resistance. Identification of the origin and emergence of this clonal complex could probably benefit future large-scale studies that aim to detect sources of contamination and infection. Current evidence indicates that the evolution of CC398 strains towards these phenotypes has been driven by the acquisition of prophages and other mobile genetic elements. In this short review, we summarize the main knowledge of this major lineage of S. aureus that has become predominant in the human clinic worldwide within a single decade. View Full-Text
Keywords: Staphylococcus aureus; CC398; evolution; prophages; mobile genetic elements Staphylococcus aureus; CC398; evolution; prophages; mobile genetic elements
Show Figures

Figure 1

MDPI and ACS Style

Laumay, F.; Benchetrit, H.; Corvaglia, A.-R.; van der Mee-Marquet, N.; François, P. The Staphylococcus aureus CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements. Genes 2021, 12, 1752. https://doi.org/10.3390/genes12111752

AMA Style

Laumay F, Benchetrit H, Corvaglia A-R, van der Mee-Marquet N, François P. The Staphylococcus aureus CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements. Genes. 2021; 12(11):1752. https://doi.org/10.3390/genes12111752

Chicago/Turabian Style

Laumay, Floriane, Hugo Benchetrit, Anna-Rita Corvaglia, Nathalie van der Mee-Marquet, and Patrice François. 2021. "The Staphylococcus aureus CC398 Lineage: An Evolution Driven by the Acquisition of Prophages and Other Mobile Genetic Elements" Genes 12, no. 11: 1752. https://doi.org/10.3390/genes12111752

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop