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Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools

1
Department of Anthropology, University of California, San Diego, La Jolla, CA 92093, USA
2
Department of Global Health, University of California, San Diego, La Jolla, CA 92093, USA
3
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
*
Authors to whom correspondence should be addressed.
Genes 2020, 11(1), 88; https://doi.org/10.3390/genes11010088
Received: 17 December 2019 / Revised: 8 January 2020 / Accepted: 9 January 2020 / Published: 12 January 2020
(This article belongs to the Special Issue Prospects in Transgenic Technology 2020)
Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within the population genetics community frequently overlook the importance of these criteria when associating observed phenotypic variation with evolutionary explanations. A functional investigation of population-specific variation using cutting-edge genome editing tools has the potential to empower the population genetics community by holding “just-so” evolutionary explanations accountable. Here, we detail currently available precision genome editing tools and methods, with a particular emphasis on base editing, that can be applied to functionally investigate population-specific point mutations. We use the recent identification of thrifty mutations in the CREBRF gene as an example of the current dire need for an alliance between the fields of population genetics and genome editing. View Full-Text
Keywords: base editing; population genetics; signatures of natural selection; functional genomics base editing; population genetics; signatures of natural selection; functional genomics
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MDPI and ACS Style

Fox, K.; Rallapalli, K.L.; Komor, A.C. Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. Genes 2020, 11, 88. https://doi.org/10.3390/genes11010088

AMA Style

Fox K, Rallapalli KL, Komor AC. Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. Genes. 2020; 11(1):88. https://doi.org/10.3390/genes11010088

Chicago/Turabian Style

Fox, Keolu, Kartik L. Rallapalli, and Alexis C. Komor 2020. "Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools" Genes 11, no. 1: 88. https://doi.org/10.3390/genes11010088

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