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Volume 10
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10.3390/genes10060440
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Article

Association between Aerobic Exercise and High-Density Lipoprotein Cholesterol Levels across Various Ranges of Body Mass Index and Waist-Hip Ratio and the Modulating Role of the Hepatic Lipase rs1800588 Variant

by
Yasser Nassef
1,
Oswald Ndi Nfor
2,
Kuan-Jung Lee
2,
Ming-Chih Chou
1,* and
Yung-Po Liaw
2,3,*
1
Institute of Medicine, Chung Shan Medical University, Taichung City 40201, Taiwan
2
Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City 40201, Taiwan
3
Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung City 40201, Taiwan
*
Authors to whom correspondence should be addressed.
Genes 2019, 10(6), 440; https://doi.org/10.3390/genes10060440
Submission received: 29 April 2019 / Revised: 29 May 2019 / Accepted: 3 June 2019 / Published: 10 June 2019
(This article belongs to the Special Issue Genetic and Epigenetic Modulation of Cell Functions by Physical Exercise)
Versions Notes

Abstract

Changes in concentrations of high-density lipoprotein cholesterol (HDL-C) are modified by several factors. We examined the relationship between aerobic exercise and HDL-C among different categories of body mass index (BMI) and waist-hip ratio (WHR) and the impact of rs1800588 variant in the hepatic lipase (LIPC) gene. We analyzed data from 6184 men and 8353 women aged 30–70 years. Participants were grouped into two WHR categories: Normal (0 < WHR < 0.9 for men and 0 < WHR < 0.8 for women) and abnormal (WHR ≥ 0.9 for men and WHR ≥ 0.8 for women). The BMI categories were: Underweight (BMI < 18.5 kg/m2), normal weight (18.5 ≤ BMI < 24 kg/m2), overweight (24 ≤ BMI < 27 kg/m2), and obese (BMI ≥ 27 kg/m2). Multivariate linear regression models were used to investigate associations between HDL-C and exercise. Aerobic exercise was significantly associated with higher HDL-C (β = 1.18325; p < 0.0001) when compared with no exercise. HDL-C was significantly lower in persons with abnormal compared to those with normal WHR (β = −3.06689; p < 0.0001). Compared with normal weight, overweight and obese categories were associated with lower HDL-C, with β values of −4.31095 and −6.44230, respectively (p < 0.0001). Unlike rs1800588 CT and TT genotypes, associations between aerobic exercise and HDL were not significant among CC carriers no matter their BMI or WHR.
Keywords: high-density lipoprotein; aerobic exercise; body fat; hepatic lipase; Taiwan Biobank high-density lipoprotein; aerobic exercise; body fat; hepatic lipase; Taiwan Biobank

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MDPI and ACS Style

Nassef, Y.; Nfor, O.N.; Lee, K.-J.; Chou, M.-C.; Liaw, Y.-P. Association between Aerobic Exercise and High-Density Lipoprotein Cholesterol Levels across Various Ranges of Body Mass Index and Waist-Hip Ratio and the Modulating Role of the Hepatic Lipase rs1800588 Variant. Genes 2019, 10, 440. https://doi.org/10.3390/genes10060440

AMA Style

Nassef Y, Nfor ON, Lee K-J, Chou M-C, Liaw Y-P. Association between Aerobic Exercise and High-Density Lipoprotein Cholesterol Levels across Various Ranges of Body Mass Index and Waist-Hip Ratio and the Modulating Role of the Hepatic Lipase rs1800588 Variant. Genes. 2019; 10(6):440. https://doi.org/10.3390/genes10060440

Chicago/Turabian Style

Nassef, Yasser, Oswald Ndi Nfor, Kuan-Jung Lee, Ming-Chih Chou, and Yung-Po Liaw. 2019. "Association between Aerobic Exercise and High-Density Lipoprotein Cholesterol Levels across Various Ranges of Body Mass Index and Waist-Hip Ratio and the Modulating Role of the Hepatic Lipase rs1800588 Variant" Genes 10, no. 6: 440. https://doi.org/10.3390/genes10060440

APA Style

Nassef, Y., Nfor, O. N., Lee, K.-J., Chou, M.-C., & Liaw, Y.-P. (2019). Association between Aerobic Exercise and High-Density Lipoprotein Cholesterol Levels across Various Ranges of Body Mass Index and Waist-Hip Ratio and the Modulating Role of the Hepatic Lipase rs1800588 Variant. Genes, 10(6), 440. https://doi.org/10.3390/genes10060440

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