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Repression of Inappropriate Gene Expression in the Vertebrate Embryonic Ectoderm

1
PhD Program in Biology, The Graduate Center, The City University of New York, New York, NY 10016, USA
2
Department of Biology, Queens College, The City University of New York, Queens, NY 11367, USA
*
Author to whom correspondence should be addressed.
Genes 2019, 10(11), 895; https://doi.org/10.3390/genes10110895
Received: 26 September 2019 / Revised: 28 October 2019 / Accepted: 4 November 2019 / Published: 6 November 2019
(This article belongs to the Special Issue Transcriptional Regulation of Early Embryogenesis)
During vertebrate embryogenesis, precise regulation of gene expression is crucial for proper cell fate determination. Much of what we know about vertebrate development has been gleaned from experiments performed on embryos of the amphibian Xenopus laevis; this review will focus primarily on studies of this model organism. An early critical step during vertebrate development is the formation of the three primary germ layers—ectoderm, mesoderm, and endoderm—which emerge during the process of gastrulation. While much attention has been focused on the induction of mesoderm and endoderm, it has become clear that differentiation of the ectoderm involves more than the simple absence of inductive cues; rather, it additionally requires the inhibition of mesendoderm-promoting genes. This review aims to summarize our current understanding of the various inhibitors of inappropriate gene expression in the presumptive ectoderm. View Full-Text
Keywords: Xenopus; development; gastrulation; ectoderm; gene regulation; pluripotency Xenopus; development; gastrulation; ectoderm; gene regulation; pluripotency
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Reich, S.; Weinstein, D.C. Repression of Inappropriate Gene Expression in the Vertebrate Embryonic Ectoderm. Genes 2019, 10, 895.

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