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Chromosomics: Bridging the Gap between Genomes and Chromosomes
Open AccessArticle

Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species

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Institute of Molecular and Cellular Biology, SB RAS, 630090 Novosibirsk, Russia
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Novosibirsk State University, 630090 Novosibirsk, Russia
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State Research Center of Virology and Biotechnology “Vector”, Federal Service for Surveillance on Consumer Rights Protection and Human Well-being (FBRI SRC VB “Vector”, Rospotrebnadzor), 630559 Koltsovo, Novosibirsk Region, Russia
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Institute for Biological Problems of Cryolithozone Siberian Branch of RAS, 677980 Yakutsk, Russia
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The Royal Veterinary College, Royal College Street, University of London, London NW1 0TU, UK
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School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK
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Frederick National Laboratory of Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA
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Theodosius Dobzhansky Center for Genome Bioinformatics, Saint-Petersburg State University, Sredniy Av. 41A, 199034 Saint-Petersburg, Russia
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Oceanographic Center, Nova Southeastern University, Fort Lauderdale 3301 College Ave, Fort Lauderdale, FL 33314, USA
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The Center for Species Survival, Department of Reproductive Sciences, Smithsonian Conservation Biology Institute, Smithsonian’s National Zoological Park, 1500 Remount Road, Front Royal, VA 22630, USA
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Author to whom correspondence should be addressed.
Genes 2019, 10(11), 857; https://doi.org/10.3390/genes10110857
Received: 17 September 2019 / Revised: 16 October 2019 / Accepted: 24 October 2019 / Published: 29 October 2019
(This article belongs to the Special Issue Mechanisms of Driving Karyotype Evolution and Genomic Architecture)
Bovidae, the largest family in Pecora infraorder, are characterized by a striking variability in diploid number of chromosomes between species and among individuals within a species. The bovid X chromosome is also remarkably variable, with several morphological types in the family. Here we built a detailed chromosome map of musk ox (Ovibos moschatus), a relic species originating from Pleistocene megafauna, with dromedary and human probes using chromosome painting. We trace chromosomal rearrangements during Bovidae evolution by comparing species already studied by chromosome painting. The musk ox karyotype differs from the ancestral pecoran karyotype by six fusions, one fission, and three inversions. We discuss changes in pecoran ancestral karyotype in the light of new painting data. Variations in the X chromosome structure of four bovid species nilgai bull (Boselaphus tragocamelus), saola (Pseudoryx nghetinhensis), gaur (Bos gaurus), and Kirk’s Dikdik (Madoqua kirkii) were further analyzed using 26 cattle BAC-clones. We found the duplication on the X in saola. We show main rearrangements leading to the formation of four types of bovid X: Bovinae type with derived cattle subtype formed by centromere reposition and Antilopinae type with Caprini subtype formed by inversion in XSB1. View Full-Text
Keywords: BAC-clones; chromosome painting; Kirk’s Dikdik; musk ox; saola; nilgai bull; gaur BAC-clones; chromosome painting; Kirk’s Dikdik; musk ox; saola; nilgai bull; gaur
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Proskuryakova, A.A.; Kulemzina, A.I.; Perelman, P.L.; Yudkin, D.V.; Lemskaya, N.A.; Okhlopkov, I.M.; Kirillin, E.V.; Farré, M.; Larkin, D.M.; Roelke-Parker, M.E.; O’Brien, S.J.; Bush, M.; Graphodatsky, A.S. Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species. Genes 2019, 10, 857.

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