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Review

Molecular Mechanisms of Heat Shock Factors in Cancer

1
Cell Biology, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6, 20520 Turku, Finland
2
Turku Bioscience, University of Turku and Åbo Akademi University, Tykistökatu 6, 20520 Turku, Finland
*
Author to whom correspondence should be addressed.
Cells 2020, 9(5), 1202; https://doi.org/10.3390/cells9051202
Received: 14 April 2020 / Revised: 8 May 2020 / Accepted: 9 May 2020 / Published: 12 May 2020
(This article belongs to the Special Issue Molecular Chaperones: Cancer and Cell Death)
Malignant transformation is accompanied by alterations in the key cellular pathways that regulate development, metabolism, proliferation and motility as well as stress resilience. The members of the transcription factor family, called heat shock factors (HSFs), have been shown to play important roles in all of these biological processes, and in the past decade it has become evident that their activities are rewired during tumorigenesis. This review focuses on the expression patterns and functions of HSF1, HSF2, and HSF4 in specific cancer types, highlighting the mechanisms by which the regulatory functions of these transcription factors are modulated. Recently developed therapeutic approaches that target HSFs are also discussed. View Full-Text
Keywords: carcinogenesis; heat shock factor; heat shock response; proteotoxic stress; transcription carcinogenesis; heat shock factor; heat shock response; proteotoxic stress; transcription
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MDPI and ACS Style

Puustinen, M.C.; Sistonen, L. Molecular Mechanisms of Heat Shock Factors in Cancer. Cells 2020, 9, 1202. https://doi.org/10.3390/cells9051202

AMA Style

Puustinen MC, Sistonen L. Molecular Mechanisms of Heat Shock Factors in Cancer. Cells. 2020; 9(5):1202. https://doi.org/10.3390/cells9051202

Chicago/Turabian Style

Puustinen, Mikael Christer, and Lea Sistonen. 2020. "Molecular Mechanisms of Heat Shock Factors in Cancer" Cells 9, no. 5: 1202. https://doi.org/10.3390/cells9051202

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