Membrane-Associated Heat Shock Proteins in Oncology: From Basic Research to New Theranostic Targets
1
Center for Translational Cancer Research Technische Universität München (TranslaTUM), Radiation Immuno-Oncology group, Klinikum rechts der Isar, Einstein Str. 25, 81675 Munich, Germany
2
Institute of Cytology of the Russian Academy of Sciences (RAS), Tikhoretsky ave., 4, 194064 St. Petersburg, Russia
3
Pavlov First Saint Petersburg State Medical University, L. Tolstogo str. 6/8, 197022 St. Petersburg, Russia
4
Almazov National Medical Research Centre, Polenov Russian Scientific Research Institute of Neurosurgery, Mayakovskogo str. 12, 191104 St. Petersburg, Russia
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National Center for Neurosurgery, Turan Ave., 34/1, Nur-Sultan 010000, Kazakhstan
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Far Eastern Federal University, Russky Island, 690000 Vladivostok, Russia
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Institute of Biochemistry and Medical Chemistry, Medical School, University of Pecs, Szigeti str. 12, 7624 Pecs, Hungary
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Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610064, China
9
Institute of Biochemistry, Biological Research Centre, Temesvári krt. 62, 6726 Szeged, Hungary
*
Author to whom correspondence should be addressed.
Cells 2020, 9(5), 1263; https://doi.org/10.3390/cells9051263
Received: 30 March 2020
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Revised: 16 May 2020
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Accepted: 18 May 2020
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Published: 20 May 2020
(This article belongs to the Special Issue Molecular Chaperones: Cancer and Cell Death)
Heat shock proteins (HSPs) constitute a large family of conserved proteins acting as molecular chaperones that play a key role in intracellular protein homeostasis, regulation of apoptosis, and protection from various stress factors (including hypoxia, thermal stress, oxidative stress). Apart from their intracellular localization, members of different HSP families such as small HSPs, HSP40, HSP60, HSP70 and HSP90 have been found to be localized on the plasma membrane of malignantly transformed cells. In the current article, the role of membrane-associated molecular chaperones in normal and tumor cells is comprehensively reviewed with implications of these proteins as plausible targets for cancer therapy and diagnostics.
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Keywords:
heat shock proteins; HSP90; GRP96; HSP70; GRP78; HSP60; HSP40; HSP27; calreticulin; targeted diagnostics and therapy
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MDPI and ACS Style
Shevtsov, M.; Balogi, Z.; Khachatryan, W.; Gao, H.; Vígh, L.; Multhoff, G. Membrane-Associated Heat Shock Proteins in Oncology: From Basic Research to New Theranostic Targets. Cells 2020, 9, 1263. https://doi.org/10.3390/cells9051263
AMA Style
Shevtsov M, Balogi Z, Khachatryan W, Gao H, Vígh L, Multhoff G. Membrane-Associated Heat Shock Proteins in Oncology: From Basic Research to New Theranostic Targets. Cells. 2020; 9(5):1263. https://doi.org/10.3390/cells9051263
Chicago/Turabian StyleShevtsov, Maxim, Zsolt Balogi, William Khachatryan, Huile Gao, László Vígh, and Gabriele Multhoff. 2020. "Membrane-Associated Heat Shock Proteins in Oncology: From Basic Research to New Theranostic Targets" Cells 9, no. 5: 1263. https://doi.org/10.3390/cells9051263
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