Next Article in Journal
HSP90 Interacts with the Fibronectin N-terminal Domains and Increases Matrix Formation
Previous Article in Journal
Nuclear Export of Cyclin B Mediated by the Nup62 Complex Is Required for Meiotic Initiation in Drosophila Males
Previous Article in Special Issue
Extrachromosomal Histone H2B Contributes to the Formation of the Abscission Site for Cell Division
Open AccessReview

Cytokinesis in Eukaryotic Cells: The Furrow Complexity at a Glance

Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
Cells 2020, 9(2), 271; https://doi.org/10.3390/cells9020271 (registering DOI)
Received: 11 December 2019 / Revised: 17 January 2020 / Accepted: 20 January 2020 / Published: 22 January 2020
(This article belongs to the Special Issue Molecular Factors and Mechanisms Involved in Cytokinesis)
The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the steps of cell division must be properly coordinated with each other to faithfully segregate the genetic material and this task is fundamental for generating viable cells. Given the importance of this process, molecular pathways and proteins that are involved in cytokinesis are conserved from yeast to humans. In this review, we describe symmetric and asymmetric cell division in animal cell and in a model organism, budding yeast. In addition, we illustrate the surveillance mechanisms that ensure a proper cell division and discuss the connections with normal cell proliferation and organs development and with the occurrence of human diseases. View Full-Text
Keywords: cell division; aneuploidy; MEN network; bud neck; model organism; tetraploidy; CIN cell division; aneuploidy; MEN network; bud neck; model organism; tetraploidy; CIN
Show Figures

Figure 1

MDPI and ACS Style

Fraschini, R. Cytokinesis in Eukaryotic Cells: The Furrow Complexity at a Glance. Cells 2020, 9, 271.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop