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Review

Recent Advances in the Development of Protein- and Peptide-Based Subunit Vaccines against Tuberculosis

by 1,2 and 2,*
1
Hevesy György PhD School of Chemistry, Eötvös Loránd University, 1117 Budapest, Hungary
2
MTA-ELTE Research Group of Peptide Chemistry, Eötvös Loránd University, 1117 Budapest, Hungary
*
Author to whom correspondence should be addressed.
Cells 2020, 9(12), 2673; https://doi.org/10.3390/cells9122673
Received: 19 November 2020 / Revised: 11 December 2020 / Accepted: 14 December 2020 / Published: 15 December 2020
(This article belongs to the Special Issue Molecular Immunology in Bacterial Vaccine Discovery)
The World Health Organization (WHO) herald of the “End TB Strategy” has defined goals and targets for tuberculosis prevention, care, and control to end the global tuberculosis endemic. The emergence of drug resistance and the relative dreadful consequences in treatment outcome has led to increased awareness on immunization against Mycobacterium tuberculosis (Mtb). However, the proven limited efficacy of Bacillus Calmette-Guérin (BCG), the only licensed vaccine against Mtb, has highlighted the need for alternative vaccines. In this review, we seek to give an overview of Mtb infection and failure of BCG to control it. Afterward, we focus on the protein- and peptide-based subunit vaccine subtype, examining the advantages and drawbacks of using this design approach. Finally, we explore the features of subunit vaccine candidates currently in pre-clinical and clinical evaluation, including the antigen repertoire, the exploited adjuvanted delivery systems, as well as the spawned immune response. View Full-Text
Keywords: Mycobacterium tuberculosis; subunit vaccine; protein-based vaccine; peptide-based vaccine; antigen; adjuvant; tuberculosis; epitope Mycobacterium tuberculosis; subunit vaccine; protein-based vaccine; peptide-based vaccine; antigen; adjuvant; tuberculosis; epitope
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MDPI and ACS Style

Bellini, C.; Horváti, K. Recent Advances in the Development of Protein- and Peptide-Based Subunit Vaccines against Tuberculosis. Cells 2020, 9, 2673. https://doi.org/10.3390/cells9122673

AMA Style

Bellini C, Horváti K. Recent Advances in the Development of Protein- and Peptide-Based Subunit Vaccines against Tuberculosis. Cells. 2020; 9(12):2673. https://doi.org/10.3390/cells9122673

Chicago/Turabian Style

Bellini, Chiara, and Kata Horváti. 2020. "Recent Advances in the Development of Protein- and Peptide-Based Subunit Vaccines against Tuberculosis" Cells 9, no. 12: 2673. https://doi.org/10.3390/cells9122673

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