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The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition

Department of Pharmacology and Toxicology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Cells 2020, 9(12), 2686; https://doi.org/10.3390/cells9122686
Received: 30 November 2020 / Revised: 10 December 2020 / Accepted: 12 December 2020 / Published: 15 December 2020
(This article belongs to the Special Issue Mitochondrial Permeability Transition)
The mitochondrial permeability transition, a Ca2+-induced significant increase in permeability of the inner mitochondrial membrane, plays an important role in various pathologies. The mitochondrial permeability transition is caused by induction of the permeability transition pore (PTP). Despite significant effort, the molecular composition of the PTP is not completely clear and remains an area of hot debate. The Ca2+-modified adenine nucleotide translocase (ANT) and F0F1 ATP synthase are the major contenders for the role of pore in the PTP. This paper briefly overviews experimental results focusing on the role of ANT in the mitochondrial permeability transition and proposes that multiple molecular entities might be responsible for the conductance pathway of the PTP. Consequently, the term PTP cannot be applied to a single specific protein such as ANT or a protein complex such as F0F1 ATP synthase, but rather should comprise a variety of potential contributors to increased permeability of the inner mitochondrial membrane. View Full-Text
Keywords: calcium; permeability transition pore; adenine nucleotide translocase; cyclophilin D; F0F1-ATP synthase calcium; permeability transition pore; adenine nucleotide translocase; cyclophilin D; F0F1-ATP synthase
MDPI and ACS Style

Brustovetsky, N. The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition. Cells 2020, 9, 2686. https://doi.org/10.3390/cells9122686

AMA Style

Brustovetsky N. The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition. Cells. 2020; 9(12):2686. https://doi.org/10.3390/cells9122686

Chicago/Turabian Style

Brustovetsky, Nickolay. 2020. "The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition" Cells 9, no. 12: 2686. https://doi.org/10.3390/cells9122686

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