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The Angiopoietin/Tie2 Pathway in Hepatocellular Carcinoma
Review

Insight into the Role of Angiopoietins in Ageing-Associated Diseases

1
Department of Clinical Gene Therapy, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
2
Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(12), 2636; https://doi.org/10.3390/cells9122636
Received: 25 October 2020 / Revised: 5 December 2020 / Accepted: 7 December 2020 / Published: 8 December 2020
(This article belongs to the Special Issue Angiopoietin Signaling)
Angiopoietin (Ang) and its receptor, TIE signaling, contribute to the development and maturation of embryonic vasculature as well as vascular remodeling and permeability in adult tissues. Targeting both this signaling pathway and the major pathway with vascular endothelial growth factor (VEGF) is expected to permit clinical applications, especially in antiangiogenic therapies against tumors. Several drugs targeting the Ang-TIE signaling pathway in cancer patients are under clinical development. Similar to how cancer increases with age, unsuitable angiogenesis or endothelial dysfunction is often seen in other ageing-associated diseases (AADs) such as atherosclerosis, Alzheimer’s disease, type 2 diabetes, chronic kidney disease and cardiovascular diseases. Thus, the Ang-TIE pathway is a possible molecular target for AAD therapy. In this review, we focus on the potential role of the Ang-TIE signaling pathway in AADs, especially non-cancer-related AADs. We also suggest translational insights and future clinical applications of this pathway in those AADs. View Full-Text
Keywords: angiopoietin; ageing; ageing-associated diseases; endothelial cells; vascular function angiopoietin; ageing; ageing-associated diseases; endothelial cells; vascular function
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MDPI and ACS Style

Hayashi, S.-i.; Rakugi, H.; Morishita, R. Insight into the Role of Angiopoietins in Ageing-Associated Diseases. Cells 2020, 9, 2636. https://doi.org/10.3390/cells9122636

AMA Style

Hayashi S-i, Rakugi H, Morishita R. Insight into the Role of Angiopoietins in Ageing-Associated Diseases. Cells. 2020; 9(12):2636. https://doi.org/10.3390/cells9122636

Chicago/Turabian Style

Hayashi, Shin-ichiro, Hiromi Rakugi, and Ryuichi Morishita. 2020. "Insight into the Role of Angiopoietins in Ageing-Associated Diseases" Cells 9, no. 12: 2636. https://doi.org/10.3390/cells9122636

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