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miRNAs as Influencers of Cell–Cell Communication in Tumor Microenvironment

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy
LTTA—Electron Microscopy Center, University of Ferrara, 44121 Ferrara, Italy
Author to whom correspondence should be addressed.
Cells 2020, 9(1), 220;
Received: 16 December 2019 / Revised: 13 January 2020 / Accepted: 14 January 2020 / Published: 15 January 2020
(This article belongs to the Collection Regulatory Functions of microRNAs)
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression. MiRNAs are involved in the control of a multiplicity of biological processes, and their absence or altered expression has been associated with a variety of human diseases, including cancer. Recently, extracellular miRNAs (ECmiRNAs) have been described as mediators of intercellular communication in multiple contexts, including tumor microenvironment. Cancer cells cooperate with stromal cells and elements of the extracellular matrix (ECM) to establish a comfortable niche to grow, to evade the immune system, and to expand. Within the tumor microenvironment, cells release ECmiRNAs and other factors in order to influence and hijack the physiological processes of surrounding cells, fostering tumor progression. Here, we discuss the role of miRNAs in the pathogenesis of multicomplex diseases, such as Alzheimer’s disease, obesity, and cancer, focusing on the contribution of both intracellular miRNAs, and of released ECmiRNAs in the establishment and development of cancer niche. We also review growing evidence suggesting the use of miRNAs as novel targets or potential tools for therapeutic applications.
Keywords: microRNA; tumor microenvironment; cell–cell communication; extracellular miRNA; cancer therapy microRNA; tumor microenvironment; cell–cell communication; extracellular miRNA; cancer therapy
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MDPI and ACS Style

Conti, I.; Varano, G.; Simioni, C.; Laface, I.; Milani, D.; Rimondi, E.; Neri, L.M. miRNAs as Influencers of Cell–Cell Communication in Tumor Microenvironment. Cells 2020, 9, 220.

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