MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues
1
Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, 17177 Stockholm, Sweden
2
Department of Oncology-Pathology, Karolinska Institutet, 17176 Stockholm, Sweden
3
Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
4
School of Biological Sciences, Nanyang Technological University Singapore, 60 Nanyang Drive, Singapore 637551, Singapore
5
Section of Virology, Division of Infectious Diseases, Department of Medicine, Imperial College London, London W2 1NY, UK
6
Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
*
Authors to whom correspondence should be addressed.
Cells 2019, 8(9), 991; https://doi.org/10.3390/cells8090991
Received: 31 July 2019
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Revised: 24 August 2019
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Accepted: 27 August 2019
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Published: 28 August 2019
(This article belongs to the Special Issue Matrix Metalloproteinases: From Structure to Function)
Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell–cell and cell–extracellular matrix (ECM) communication. This regulation mediates processes such as ECM degradation and remodeling, cell invasion, and cancer metastasis. Thus, a comprehensive understanding of the biology of MMP14 in sarcomas will shed light on the mechanisms controlling the key processes in these diseases. Here, we provide an overview of the function and regulation of MMP14 and we discuss their relationship with clinical and pre-clinical MMP14 data in both adult and childhood sarcomas.
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Keywords:
MMP14; sarcoma; tumor microenvironment; mesenchymal phenotype; metastasis
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MDPI and ACS Style
Gonzalez-Molina, J.; Gramolelli, S.; Liao, Z.; Carlson, J.W.; Ojala, P.M.; Lehti, K. MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues. Cells 2019, 8, 991. https://doi.org/10.3390/cells8090991
AMA Style
Gonzalez-Molina J, Gramolelli S, Liao Z, Carlson JW, Ojala PM, Lehti K. MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues. Cells. 2019; 8(9):991. https://doi.org/10.3390/cells8090991
Chicago/Turabian StyleGonzalez-Molina, Jordi, Silvia Gramolelli, Zehuan Liao, Joseph W. Carlson, Päivi M. Ojala, and Kaisa Lehti. 2019. "MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues" Cells 8, no. 9: 991. https://doi.org/10.3390/cells8090991
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