Circular RNA Regulation of Myogenesis
Abstract
:1. Introduction
2. CircRNA Biogenesis
2.1. Diversity of CircRNAs
2.2. Direct Back Splicing Model
2.3. Exon Skipping Model
2.4. CiRNAs Biogenesis
3. The Regulatory Roles of CircRNAs
3.1. CircRNAs Serve as Microrna Sponge to Regulate Gene Expression
3.2. CircRNAs Regulate Transcription
3.3. CircRNAs Affects Splicing of Their Linear Cognates
3.4. CircRNAs Regulate Protein Functions
3.5. CircRNAs Encode Proteins
4. CircRNA Expression in Skeletal Muscle
5. The Functions of CircRNAs in Myogenesis
5.1. Circ-ZNF609
5.2. CircRBFOX2
5.3. CircSVIL
5.4. CircLMO7
5.5. CircFUT10
5.6. CircSNX29
5.7. CircFGFR4
5.8. CircFGFR2
5.9. CircHIPK3
5.10. CircDystrophy
6. Perspective
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Organism | Sample | Treatment of RNA Library | Number of CircRNAs | Method for CircRNA Identification | References |
---|---|---|---|---|---|
Macaca mulatta | vastus lateralis muscle | RNase R | 12,007 | circExplorer | 2015 [44] |
Ovis aries | longissimus muscle | RNase R+ | 6113 | - | 2017 [45] |
Sus scrofa | longissimus muscle | - | 1489 | find_circ | 2017 [46] |
Gallus gallus | Leg muscle | rRNA−, RNase R+ | 13,377 | CIRI | 2017 [48] |
Bos taurus | longissimus | rRNA−, RNase R | 12,981 | - | 2017 [47] |
Homan sapines | Primary myoblast | rRNA− | 2175 | FindCirc | 2017 [14] |
Mus musculus | C2C12 cell line | rRNA− | 1592 | FindCirc | 2017 [14] |
Mus musculus | C2C12 cell line | rRNA− and RNase R+ | 37,751 | CIRI | 2018 [15] |
CircRNA | Biological Roles | Mechanism | References |
---|---|---|---|
circ-ZNF609 | promotes myoblasts proliferation and inhibits myogenesis | miR-194-5p sponge | [14,51] |
circRBFOX2 | promotes myoblasts proliferation | mir-206 sponge | [48] |
circSVIL | promotes myogenesis | miR-203 sponge | [54] |
circLMO7 | inhibits myoblasts differentiation and promotes myogenesis | miR-378a-3p sponge | [56] |
circFUT10 | inhibits myoblasts proliferation and promotes myogenesis | miR-133a sponge | [58] |
circSNX29 | promotes myogenesis | miR-744 sponge | [60] |
circFGFR4 | promotes myogenesis | miR-107 sponge | [62] |
circFGFR2 | promotes myoblast proliferation and myogenesis | miR-133a-5p and miR-29b-1-5p sponge | [64] |
circHIPK3 | promotes myoblasts proliferation and myogenesis | miR-30a-3p sponge | [67] |
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Zhang, P.; Chao, Z.; Zhang, R.; Ding, R.; Wang, Y.; Wu, W.; Han, Q.; Li, C.; Xu, H.; Wang, L.; et al. Circular RNA Regulation of Myogenesis. Cells 2019, 8, 885. https://doi.org/10.3390/cells8080885
Zhang P, Chao Z, Zhang R, Ding R, Wang Y, Wu W, Han Q, Li C, Xu H, Wang L, et al. Circular RNA Regulation of Myogenesis. Cells. 2019; 8(8):885. https://doi.org/10.3390/cells8080885
Chicago/Turabian StyleZhang, Pengpeng, Zhe Chao, Rui Zhang, Ruoqi Ding, Yaling Wang, Wei Wu, Qiu Han, Cencen Li, Haixia Xu, Lei Wang, and et al. 2019. "Circular RNA Regulation of Myogenesis" Cells 8, no. 8: 885. https://doi.org/10.3390/cells8080885