Next Article in Journal
Activation of Cryptic 3′ Splice-Sites by SRSF2 Contributes to Cassette Exon Skipping
Next Article in Special Issue
Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight
Previous Article in Journal
Effects of Cigarette Smoke on TSPO-related Mitochondrial Processes
Previous Article in Special Issue
Osteopontin Gene Polymorphism and Urinary OPN Excretion in Patients with Immunoglobulin A Nephropathy
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 8
Issue 7
10.3390/cells8070695
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Brief Report

Osteopontin in the Cerebrospinal Fluid of Patients with Severe Aneurysmal Subarachnoid Hemorrhage

by
Maria Giulia Abate
1,†,
Lorenza Moretto
2,†,
Ilaria Licari
2,
Teresa Esposito
2,
Lorenzo Capuano
2,
Carlo Olivieri
3,
Arnaldo Benech
2,4,
Matteo Brucoli
2,4,
Gian Carlo Avanzi
2,5,
Gianmaria Cammarota
6,
Umberto Dianzani
7,8,
Nausicaa Clemente
7,
Gabriele Panzarasa
9,
Giuseppe Citerio
1,
Fabio Carfagna
2,
Giuseppe Cappellano
7,
Francesco Della Corte
2,6 and
Rosanna Vaschetto
2,6,*
1
School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy, Neurointensive Care, San Gerardo Hospital, ASST-Monza, 20900 Monza, Italy
2
Department of Translational Medicine, Università degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Italy
3
Anesthesia and Intensive Care, Sant’Andrea Hospital, Mario Abbiate, 21, 13100 Vercelli (VC), Italy
4
Maxillo facial surgery, “Maggiore della Carità” University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy
5
Emergency Department, “Maggiore della Carità” University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy
6
Anesthesia and Intensive Care, “Maggiore della Carità” University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy
7
CAAD, IRCAD, Department of Health Sciences, Università degli Studi del Piemonte Orientale, Corso Trieste 15, 28100 Novara (NO), Italy
8
Biochemical Chemistry, “Maggiore della Carità” University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy
9
Neurosurgery “Maggiore della Carità” University Hospital, Corso Mazzini 18, 28100 Novara (NO), Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2019, 8(7), 695; https://doi.org/10.3390/cells8070695
Submission received: 27 May 2019 / Revised: 1 July 2019 / Accepted: 8 July 2019 / Published: 10 July 2019
(This article belongs to the Special Issue Adding New Pieces in the Osteopontin Puzzle)
Browse Figures
Versions Notes

Abstract

Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality. In SAH patients, plasma osteopontin (OPN) has been shown to independently predict poor outcome. The aim of the study is to investigate, in a selected population with severe SAH, OPN time course in cerebrospinal fluid (CSF) and plasma during the first week after aneurism rupture, and OPN prognostic value. We included 44 patients with the following criteria: (1) age 18 and 80 years, (2) diagnosis of SAH from cerebral aneurysm rupture, (3) insertion of external ventricular drain. Plasma and CSF were sampled at day 1, 4, and 8. OPN levels, in CSF and plasma, displayed a weak correlation on day 1 and were higher, in CSF, in all time points. Only in poor prognosis patients, OPN levels in CSF significantly increased at day 4 and day 8. Plasma OPN at day 1 and 4 was predictor of poor outcome. In conclusion, plasma and CSF OPN displays a weak correlation, on day 1. The higher levels of OPN found in the CSF compared to plasma, suggest OPN production within the CNS after SAH. Furthermore, plasma OPN, at day 1 and 4, seems to be an independent predictor of poor outcome.
Keywords: osteopontin; subarachnoid hemorrhage; cerebrospinal fluid; inflammation; biomarker osteopontin; subarachnoid hemorrhage; cerebrospinal fluid; inflammation; biomarker

Share and Cite

MDPI and ACS Style

Abate, M.G.; Moretto, L.; Licari, I.; Esposito, T.; Capuano, L.; Olivieri, C.; Benech, A.; Brucoli, M.; Avanzi, G.C.; Cammarota, G.; et al. Osteopontin in the Cerebrospinal Fluid of Patients with Severe Aneurysmal Subarachnoid Hemorrhage. Cells 2019, 8, 695. https://doi.org/10.3390/cells8070695

AMA Style

Abate MG, Moretto L, Licari I, Esposito T, Capuano L, Olivieri C, Benech A, Brucoli M, Avanzi GC, Cammarota G, et al. Osteopontin in the Cerebrospinal Fluid of Patients with Severe Aneurysmal Subarachnoid Hemorrhage. Cells. 2019; 8(7):695. https://doi.org/10.3390/cells8070695

Chicago/Turabian Style

Abate, Maria Giulia, Lorenza Moretto, Ilaria Licari, Teresa Esposito, Lorenzo Capuano, Carlo Olivieri, Arnaldo Benech, Matteo Brucoli, Gian Carlo Avanzi, Gianmaria Cammarota, and et al. 2019. "Osteopontin in the Cerebrospinal Fluid of Patients with Severe Aneurysmal Subarachnoid Hemorrhage" Cells 8, no. 7: 695. https://doi.org/10.3390/cells8070695

APA Style

Abate, M. G., Moretto, L., Licari, I., Esposito, T., Capuano, L., Olivieri, C., Benech, A., Brucoli, M., Avanzi, G. C., Cammarota, G., Dianzani, U., Clemente, N., Panzarasa, G., Citerio, G., Carfagna, F., Cappellano, G., Della Corte, F., & Vaschetto, R. (2019). Osteopontin in the Cerebrospinal Fluid of Patients with Severe Aneurysmal Subarachnoid Hemorrhage. Cells, 8(7), 695. https://doi.org/10.3390/cells8070695

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop