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Open AccessEditorial

Exploring Cellular Stress Response and Chaperones

Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, Viale Europa 11, 25123 Brescia, Italy
Interdepartmental University Center of Research “Adaptation and Regeneration of Tissues and Organs-(ARTO)”, University of Brescia, 25123 Brescia, Italy
Cells 2019, 8(5), 408;
Received: 30 April 2019 / Accepted: 2 May 2019 / Published: 2 May 2019
(This article belongs to the Special Issue Cellular Stress Response in Health and Disease)
Since the pioneering discovery of heat shock proteins in Drosophila by Ferruccio Ritossa in 1960s, a long and exciting journey has been undertaken by molecular biologists and researchers worldwide. Not only lower organisms like worms, yeast, amoeba, and flies but also eukaryotes share common cellular response signals to stressful conditions that can arise from the outside but also from the inside. Moreover, extraordinary interplay between nucleus and subcellular organelles, and between different organelles, like mitochondria and the endoplasmic reticulum called mitochondria-associated endoplasmic reticulum membranes (MAMs), are involved in aging and human diseases like obesity, diabetes, inflammation, neurodegeneration, autoimmune diseases, atherosclerosis, and cancer. Actually, we know that to hit abnormal proteostasis and lipid exchanges in the endoplasmic reticulum is crucial to best guide effective therapies or discover new drugs. Indeed, restoration or impairment of endoplasmic reticulum shape and function lead to cellular homeostasis by autophagy or to final death generally by apoptosis or pyroptosis. This Special Issue collects current valuable articles or reviews on cellular stress research and each contribution opens a new window for further studies and hypothesis. I hope that readers interested in this fascinating topic may be stimulated to know more and more. View Full-Text
Keywords: heat shock proteins; endoplasmic reticulum stress; mitochondria; MAMs; autophagy; proteostasis heat shock proteins; endoplasmic reticulum stress; mitochondria; MAMs; autophagy; proteostasis
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Stacchiotti, A. Exploring Cellular Stress Response and Chaperones. Cells 2019, 8, 408.

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