Next Article in Journal
Telomere Function and the G-Quadruplex Formation are Regulated by hnRNP U
Next Article in Special Issue
Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology
Previous Article in Journal
MAGI1 Mediates eNOS Activation and NO Production in Endothelial Cells in Response to Fluid Shear Stress
Previous Article in Special Issue
Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms’ Tumor Suppressor Wt1
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessReview

Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer

Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 389;
Received: 9 April 2019 / Revised: 19 April 2019 / Accepted: 23 April 2019 / Published: 28 April 2019
(This article belongs to the Special Issue Angiogenesis in Cancer)
PDF [1327 KB, uploaded 28 April 2019]


Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its functions in cell signaling, recent evidence suggests that cholesterol plays a key role in regulating angiogenesis. This review discusses the role of cholesterol in angiogenesis, with a particular emphasis on cholesterol trafficking in endothelial cell signaling. Small molecule inhibitors of cholesterol trafficking and their preclinical and clinical development targeting angiogenesis and cancer are also discussed. View Full-Text
Keywords: cholesterol trafficking; angiogenesis; lysosome; NPC1; mTOR cholesterol trafficking; angiogenesis; lysosome; NPC1; mTOR

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Lyu, J.; Yang, E.J.; Shim, J.S. Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer. Cells 2019, 8, 389.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top