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Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer

Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China
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Cells 2019, 8(5), 389; https://doi.org/10.3390/cells8050389
Received: 9 April 2019 / Revised: 19 April 2019 / Accepted: 23 April 2019 / Published: 28 April 2019
(This article belongs to the Special Issue Angiogenesis in Cancer)
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Abstract

Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its functions in cell signaling, recent evidence suggests that cholesterol plays a key role in regulating angiogenesis. This review discusses the role of cholesterol in angiogenesis, with a particular emphasis on cholesterol trafficking in endothelial cell signaling. Small molecule inhibitors of cholesterol trafficking and their preclinical and clinical development targeting angiogenesis and cancer are also discussed. View Full-Text
Keywords: cholesterol trafficking; angiogenesis; lysosome; NPC1; mTOR cholesterol trafficking; angiogenesis; lysosome; NPC1; mTOR
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lyu, J.; Yang, E.J.; Shim, J.S. Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer. Cells 2019, 8, 389.

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