Next Article in Journal
Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy
Next Article in Special Issue
Improved Antitumor Efficacy of Combined Vaccine Based on the Induced HUVECs and DC-CT26 Against Colorectal Carcinoma
Previous Article in Journal
Application of Cancer Organoid Model for Drug Screening and Personalized Therapy
Previous Article in Special Issue
Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer
Open AccessReview

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology

Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 471;
Received: 17 April 2019 / Revised: 6 May 2019 / Accepted: 16 May 2019 / Published: 17 May 2019
(This article belongs to the Special Issue Angiogenesis in Cancer)
PDF [1492 KB, uploaded 17 May 2019]


Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized are angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2). Ang1 is a potent angiogenic growth factor signaling through Tie2, whereas Ang2 was initially identified as a vascular disruptive agent with antagonistic activity through the same receptor. Recent data demonstrates that Ang2 has context-dependent agonist activities. Ang2 plays important roles in physiological processes and the deregulation of its expression is characteristic of several diseases. In this review, we summarize the activity of Ang2 on blood and lymphatic endothelial cells, its significance in human physiology and disease, and provide a current view of the molecular signaling pathways regulated by Ang2 in endothelial cells. View Full-Text
Keywords: angiopoietin-2; Tie1; Tie2; integrin; angiogenesis; endothelial cells; cancer; inflammation angiopoietin-2; Tie1; Tie2; integrin; angiogenesis; endothelial cells; cancer; inflammation

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Akwii, R.G.; Sajib, M.S.; Zahra, F.T.; Mikelis, C.M. Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology. Cells 2019, 8, 471.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top