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Cells 2019, 8(2), 90; https://doi.org/10.3390/cells8020090

Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease

1,*,†
and
2,*,†
1
Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximilians University Munich, D-82152 Martinsried, Germany
2
The Feinstein Institute for Medical Research, The Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, Northwell Health System, Manhasset, NY 11030, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 9 January 2019 / Revised: 23 January 2019 / Accepted: 23 January 2019 / Published: 27 January 2019
(This article belongs to the Special Issue Aquaporins)
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Abstract

Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The role of AQP4 has been studied in health and in a range of pathological conditions. Interest in AQP4 has increased since it was discovered to be the target antigen in the inflammatory autoimmune disease neuromyelitis optica spectrum disorder (NMOSD). Emerging data suggest that AQP4 may also be implicated in the glymphatic system and may be involved in the clearance of beta-amyloid in Alzheimer’s disease (AD). In this review, we will describe the role of AQP4 in the adult and developing brain as well as its implication for disease. View Full-Text
Keywords: aquaporin-4; autoantibodies; disease; development; neuromyelitis optica spectrum disorder; glymphatic system aquaporin-4; autoantibodies; disease; development; neuromyelitis optica spectrum disorder; glymphatic system
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Mader, S.; Brimberg, L. Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease. Cells 2019, 8, 90.

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