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Cells 2019, 8(2), 91;

Autophagy: Dual Response in the Development of Hepatocellular Carcinoma

Department of Surgery, University of Pittsburgh, Pittsburg, PA 15213-2582, USA
Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, N924 Doan Hall, 410 West 10th Ave., Columbus, OH 43210, USA
Author to whom correspondence should be addressed.
Received: 31 December 2018 / Revised: 22 January 2019 / Accepted: 26 January 2019 / Published: 28 January 2019
(This article belongs to the Special Issue Autophagy in Tissue Injury and Homeostasis)
Full-Text   |   PDF [667 KB, uploaded 28 January 2019]   |  


Autophagy is an evolutionary conserved intracellular mechanism which helps eukaryotic cells in maintaining their metabolic state to afford high-efficiency energy requirements. In the physiology of a normal liver and the pathogenesis of liver diseases, autophagy plays a crucial role. Autophagy has been found to be both upregulated and downregulated in different cancers providing the evidence that autophagy plays a dual role in suppressing and promoting cell survival. Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the major leading cause of cancer mortality worldwide. In light of its high complexity and poor prognosis, it is essential to improve our understanding of autophagy’s role in HCC. In this review, we summarize the dual mechanism of autophagy in the development of HCC and elucidate the currently used therapeutic strategies for anti-HCC therapy. View Full-Text
Keywords: hepatocellular carcinoma; inflammation; mitophagy; oxidative stress; HCC therapy hepatocellular carcinoma; inflammation; mitophagy; oxidative stress; HCC therapy

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Yazdani, H.O.; Huang, H.; Tsung, A. Autophagy: Dual Response in the Development of Hepatocellular Carcinoma. Cells 2019, 8, 91.

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