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Germinal Centre B Cell Functions and Lymphomagenesis: Circuits Involving MYC and MicroRNAs

Programa de Pesquisa em Hemato-Oncologia Molecular, Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, CEP: 20230-130, Brazil
Author to whom correspondence should be addressed.
These authors have contributed equally.
Cells 2019, 8(11), 1365;
Received: 6 August 2019 / Revised: 30 September 2019 / Accepted: 29 October 2019 / Published: 31 October 2019
(This article belongs to the Special Issue Regulatory Functions of microRNAs)
Background: The transcription factor MYC regulates several biological cellular processes, and its target gene network comprises approximately 15% of all human genes, including microRNAs (miRNAs), that also contribute to MYC regulatory activity. Although miRNAs are emerging as key regulators of immune functions, the specific roles of miRNAs in the regulation/dysregulation of germinal centre B-cells and B-cell lymphomas are still being uncovered. The regulatory network that integrates MYC, target genes and miRNAs is a field of intense study, highlighting potential pathways to be explored in the context of future clinical approaches. Methods: The scientific literature that is indexed in PUBMED was consulted for publications involving MYC and miRNAs with validated bioinformatics analyses or experimental protocols. Additionally, seminal studies on germinal centre B-cell functions and lymphomagenesis were reported. Conclusions: This review summarizes the interactions between MYC and miRNAs through regulatory loops and circuits involving target genes in germinal centre B-cell lymphomas with MYC alterations. Moreover, we provide an overview of the understanding of the regulatory networks between MYC and miRNAs, highlighting the potential implication of this approach for the comprehension of germinal centre B-cell lymphoma pathogenesis. Therefore, circuits involving MYC, target genes and miRNAs provide novel insight into lymphomagenesis that could be useful for new improved therapeutic strategies. View Full-Text
Keywords: MYC; microRNA; germinal centre-derived lymphomas; feed-forward loop; feedback loop MYC; microRNA; germinal centre-derived lymphomas; feed-forward loop; feedback loop
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MDPI and ACS Style

Robaina, M.C.; Mazzoccoli, L.; Esteves Klumb, C. Germinal Centre B Cell Functions and Lymphomagenesis: Circuits Involving MYC and MicroRNAs. Cells 2019, 8, 1365.

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