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Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-Angiotensin System

1
Department of Neurosurgery, Wellington Regional Hospital, Wellington 6021, New Zealand
2
Gillies McIndoe Research Institute, Wellington 6021, New Zealand
3
Department of Surgery, The University of Melbourne, Parkville, VIC 3050, Australia
4
Department of Neurosurgery, Hadassah Hebrew University Medical Centre, Jerusalem 91120, Israel
5
Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC 3050, Australia
6
Wellington Regional Plastic, Maxillofacial & Burns Unit, Hutt Hospital, Lower Hutt 5040, New Zealand
*
Author to whom correspondence should be addressed.
Cells 2019, 8(11), 1364; https://doi.org/10.3390/cells8111364
Received: 27 September 2019 / Revised: 23 October 2019 / Accepted: 29 October 2019 / Published: 31 October 2019
Patients with glioblastoma (GB), a highly aggressive brain tumor, have a median survival of 14.6 months following neurosurgical resection and adjuvant chemoradiotherapy. Quiescent GB cancer stem cells (CSCs) invariably cause local recurrence. These GB CSCs can be identified by embryonic stem cell markers, express components of the renin-angiotensin system (RAS) and are associated with circulating CSCs. Despite the presence of circulating CSCs, GB patients rarely develop distant metastasis outside the central nervous system. This paper reviews the current literature on GB growth inhibition in relation to CSCs, circulating CSCs, the RAS and the novel therapeutic approach by repurposing drugs that target the RAS to improve overall symptom-free survival and maintain quality of life. View Full-Text
Keywords: glioblastoma; renin-angiotensin system; cancer stem cells; drug repurposing glioblastoma; renin-angiotensin system; cancer stem cells; drug repurposing
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MDPI and ACS Style

Tan, D.C.H.; Roth, I.M.; Wickremesekera, A.C.; Davis, P.F.; Kaye, A.H.; Mantamadiotis, T.; Stylli, S.S.; Tan, S.T. Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-Angiotensin System. Cells 2019, 8, 1364. https://doi.org/10.3390/cells8111364

AMA Style

Tan DCH, Roth IM, Wickremesekera AC, Davis PF, Kaye AH, Mantamadiotis T, Stylli SS, Tan ST. Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-Angiotensin System. Cells. 2019; 8(11):1364. https://doi.org/10.3390/cells8111364

Chicago/Turabian Style

Tan, David C.H., Imogen M. Roth, Agadha C. Wickremesekera, Paul F. Davis, Andrew H. Kaye, Theo Mantamadiotis, Stanley S. Stylli, and Swee T. Tan 2019. "Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-Angiotensin System" Cells 8, no. 11: 1364. https://doi.org/10.3390/cells8111364

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