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Open AccessReview

MicroRNAs in Uteroplacental Vascular Dysfunction

Lawrence D. Longo MD Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
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Cells 2019, 8(11), 1344; https://doi.org/10.3390/cells8111344
Received: 3 October 2019 / Revised: 26 October 2019 / Accepted: 27 October 2019 / Published: 29 October 2019
(This article belongs to the Special Issue Regulatory Functions of microRNAs)
Pregnancy complications of preeclampsia and intrauterine growth restriction (IUGR) are major causes of maternal and perinatal/neonatal morbidity and mortality. Although their etiologies remain elusive, it is generally accepted that they are secondary to placental insufficiency conferred by both failure in spiral artery remodeling and uteroplacental vascular malfunction. MicroRNAs (miRNAs) are small no-coding RNA molecules that regulate gene expression at the post-transcriptional level. Increasing evidence suggests that miRNAs participate in virtually all biological processes and are involved in numerous human diseases. Differentially expressed miRNAs in the placenta are typical features of both preeclampsia and IUGR. Dysregulated miRNAs target genes of various signaling pathways in uteroplacental tissues, contributing to the development of both complications. In this review, we provide an overview of how aberrant miRNA expression in preeclampsia and IUGR impacts the expression of genes involved in trophoblast invasion and uteroplacental vascular adaptation. View Full-Text
Keywords: miRNA; trophoblast invasion; uterine vascular adaptation; preeclampsia; intrauterine growth restriction miRNA; trophoblast invasion; uterine vascular adaptation; preeclampsia; intrauterine growth restriction
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Hu, X.-Q.; Zhang, L. MicroRNAs in Uteroplacental Vascular Dysfunction. Cells 2019, 8, 1344.

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