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Cells 2018, 7(7), 70; https://doi.org/10.3390/cells7070070

Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6

1
Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Università Vita-Salute San Raffaele, 20132 Milan, Italy
2
Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, 20132 Milan, Italy
3
Division of Immunology, Transplantation and Infectious Immunity, IRCCS Ospedale San Raffaele, 20132 Milan, Italy
4
Unit of Nephrology, IRCCS Ospedale San Raffaele, 20132 Milan, Italy
*
Author to whom correspondence should be addressed.
Received: 11 June 2018 / Revised: 27 June 2018 / Accepted: 29 June 2018 / Published: 4 July 2018
(This article belongs to the Special Issue TRP Channels in Health and Disease)
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Abstract

Allergy and autoimmune diseases are characterised by a multifactorial pathogenic background. Several genes involved in the control of innate and adaptive immunity have been associated with diseases and variably combine with each other as well as with environmental factors and epigenetic processes to shape the characteristics of individual manifestations. Systemic or local perturbations in salt/water balance and in ion exchanges between the intra- and extracellular spaces or among tissues play a role. In this field, usually referred to as elementary immunology, novel evidence has been recently acquired on the role of members of the transient potential receptor (TRP) channel family in several cellular mechanisms of potential significance for the pathophysiology of the immune response. TRP canonical channel 6 (TRPC6) is emerging as a functional element for the control of calcium currents in immune-committed cells and target tissues. In fact, TRPC6 influences leukocytes’ tasks such as transendothelial migration, chemotaxis, phagocytosis and cytokine release. TRPC6 also modulates the sensitivity of immune cells to apoptosis and influences tissue susceptibility to ischemia-reperfusion injury and excitotoxicity. Here, we provide a view of the interactions between ion exchanges and inflammation with a focus on the pathogenesis of immune-mediated diseases and potential future therapeutic implications. View Full-Text
Keywords: TRPC6; elementary immunology; inflammation; calcium; sodium; neutrophils; lymphocytes; endothelium; platelets TRPC6; elementary immunology; inflammation; calcium; sodium; neutrophils; lymphocytes; endothelium; platelets
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Ramirez, G.A.; Coletto, L.A.; Sciorati, C.; Bozzolo, E.P.; Manunta, P.; Rovere-Querini, P.; Manfredi, A.A. Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6. Cells 2018, 7, 70.

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