Mitochondrial Metabolism in Major Neurological Diseases
AbstractMitochondria are bilayer sub-cellular organelles that are an integral part of normal cellular physiology. They are responsible for producing the majority of a cell’s ATP, thus supplying energy for a variety of key cellular processes, especially in the brain. Although energy production is a key aspect of mitochondrial metabolism, its role extends far beyond energy production to cell signaling and epigenetic regulation–functions that contribute to cellular proliferation, differentiation, apoptosis, migration, and autophagy. Recent research on neurological disorders suggest a major metabolic component in disease pathophysiology, and mitochondria have been shown to be in the center of metabolic dysregulation and possibly disease manifestation. This review will discuss the basic functions of mitochondria and how alterations in mitochondrial activity lead to neurological disease progression. View Full-Text
Share & Cite This Article
Zhou, Z.; Austin, G.L.; Young, L.E.A.; Johnson, L.A.; Sun, R. Mitochondrial Metabolism in Major Neurological Diseases. Cells 2018, 7, 229.
Zhou Z, Austin GL, Young LEA, Johnson LA, Sun R. Mitochondrial Metabolism in Major Neurological Diseases. Cells. 2018; 7(12):229.Chicago/Turabian Style
Zhou, Zhengqiu; Austin, Grant L.; Young, Lyndsay E.A.; Johnson, Lance A.; Sun, Ramon. 2018. "Mitochondrial Metabolism in Major Neurological Diseases." Cells 7, no. 12: 229.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.