Next Article in Journal
Influence of SARS-CoV-2 on Adult Human Neurogenesis
Next Article in Special Issue
Relationship between Oxidative Stress and Left Ventricle Markers in Patients with Chronic Heart Failure
Previous Article in Journal
Implication of Oxysterols in Infectious and Non-Communicable Inflammatory Diseases
Previous Article in Special Issue
The Role of Oxidative Stress in Atherosclerosis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cells
Volume 12
Issue 2
10.3390/cells12020242
cells-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

The Roles of Bone Marrow-Derived Stem Cells in Coronary Collateral Growth Induced by Repetitive Ischemia

by
Molly Enrick
1,
Anurag Jamaiyar
1,
Vahagn Ohanyan
1,
Cody Juguilon
1,
Christopher Kolz
1,
Xin Shi
1,
Danielle Janota
1,
Weiguo Wan
1,
Devan Richardson
1,
Kelly Stevanov
1,
Tatevik Hakobyan
1,
Lindsay Shockling
1,
Arianna Diaz
1,
Sharon Usip
2,
Feng Dong
1,
Ping Zhang
1,
William M. Chilian
1,* and
Liya Yin
1,*
1
Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA
2
Department of Anatomy and Neuroscience, Northeast Ohio Medical University, Rootstown, OH 44272, USA
*
Authors to whom correspondence should be addressed.
Cells 2023, 12(2), 242; https://doi.org/10.3390/cells12020242
Submission received: 7 December 2022 / Revised: 29 December 2022 / Accepted: 4 January 2023 / Published: 6 January 2023
(This article belongs to the Special Issue The Role of Oxidative Stress in Cardiovascular Diseases)
Browse Figures
Versions Notes

Abstract

Many clinical trials have attempted to use stem cells to treat ischemic heart diseases (IHD), but the benefits have been modest. Though coronary collaterals can be a “natural bypass” for IHD patients, the regulation of coronary collateral growth (CCG) and the role of endogenous stem cells in CCG are not fully understood. In this study, we used a bone marrow transplantation scheme to study the role of bone marrow stem cells (BMSCs) in a rat model of CCG. Transgenic GFP rats were used to trace BMSCs after transplantation; GFP bone marrow was harvested or sorted for bone marrow transplantation. After recovering from transplantation, the recipient rats underwent 10 days of repetitive ischemia (RI), with echocardiography before and after RI, to measure cardiac function and myocardial blood flow. At the end of RI, the rats were sacrificed for the collection of bone marrow for flow cytometry or heart tissue for imaging analysis. Our study shows that upon RI stimulation, BMSCs homed to the recipient rat hearts’ collateral-dependent zone (CZ), proliferated, differentiated into endothelial cells, and engrafted in the vascular wall for collateral growth. These RI-induced collaterals improved coronary blood flow and cardiac function in the recipients’ hearts during ischemia. Depletion of donor CD34+ BMSCs led to impaired CCG in the recipient rats, indicating that this cell population is essential to the process. Overall, these results show that BMSCs contribute to CCG and suggest that regulation of the function of BMSCs to promote CCG might be a potential therapeutic approach for IHD.
Keywords: bone marrow stem cells; coronary collateral growth; repetitive ischemia; coronary blood flow; coronary microcirculation bone marrow stem cells; coronary collateral growth; repetitive ischemia; coronary blood flow; coronary microcirculation

Share and Cite

MDPI and ACS Style

Enrick, M.; Jamaiyar, A.; Ohanyan, V.; Juguilon, C.; Kolz, C.; Shi, X.; Janota, D.; Wan, W.; Richardson, D.; Stevanov, K.; et al. The Roles of Bone Marrow-Derived Stem Cells in Coronary Collateral Growth Induced by Repetitive Ischemia. Cells 2023, 12, 242. https://doi.org/10.3390/cells12020242

AMA Style

Enrick M, Jamaiyar A, Ohanyan V, Juguilon C, Kolz C, Shi X, Janota D, Wan W, Richardson D, Stevanov K, et al. The Roles of Bone Marrow-Derived Stem Cells in Coronary Collateral Growth Induced by Repetitive Ischemia. Cells. 2023; 12(2):242. https://doi.org/10.3390/cells12020242

Chicago/Turabian Style

Enrick, Molly, Anurag Jamaiyar, Vahagn Ohanyan, Cody Juguilon, Christopher Kolz, Xin Shi, Danielle Janota, Weiguo Wan, Devan Richardson, Kelly Stevanov, and et al. 2023. "The Roles of Bone Marrow-Derived Stem Cells in Coronary Collateral Growth Induced by Repetitive Ischemia" Cells 12, no. 2: 242. https://doi.org/10.3390/cells12020242

APA Style

Enrick, M., Jamaiyar, A., Ohanyan, V., Juguilon, C., Kolz, C., Shi, X., Janota, D., Wan, W., Richardson, D., Stevanov, K., Hakobyan, T., Shockling, L., Diaz, A., Usip, S., Dong, F., Zhang, P., Chilian, W. M., & Yin, L. (2023). The Roles of Bone Marrow-Derived Stem Cells in Coronary Collateral Growth Induced by Repetitive Ischemia. Cells, 12(2), 242. https://doi.org/10.3390/cells12020242

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop