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Review

Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond

by
Peter M. Benz
1,2,*,†,
Timo Frömel
1,
Hebatullah Laban
1,
Joana Zink
1,
Lea Ulrich
1,
Dieter Groneberg
3,
Reinier A. Boon
2,4,5,6,
Philip Poley
7,8,
Thomas Renne
9,10,11,
Cor de Wit
7,8 and
Ingrid Fleming
1,2,4
1
Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, 60596 Frankfurt am Main, Germany
2
German Centre of Cardiovascular Research (DZHK), Partner Site Rhein-Main, 60596 Frankfurt am Main, Germany
3
Institute of Physiology I, University of Würzburg, 97070 Würzburg, Germany
4
Cardiopulmonary Institute, 60596 Frankfurt am Main, Germany
5
Centre of Molecular Medicine, Institute of Cardiovascular Regeneration, Goethe-University, 60596 Frankfurt am Main, Germany
6
Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Centre, 1081 HZ Amsterdam, The Netherlands
7
Institut für Physiologie, Universität zu Lübeck, 23562 Lübeck, Germany
8
German Centre of Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 23562 Lübeck, Germany
9
Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
10
Center for Thrombosis and Hemostasis (CTH), Johannes Gutenberg University Medical Center, 55131 Mainz, Germany
11
Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, D02 VN51 Dublin, Ireland
 
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*
Author to whom correspondence should be addressed.
†
Current address: Department of CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach, Germany.
Cells 2023, 12(13), 1740; https://doi.org/10.3390/cells12131740
Submission received: 26 April 2023 / Revised: 18 June 2023 / Accepted: 21 June 2023 / Published: 28 June 2023
(This article belongs to the Special Issue Exclusive Review Papers in "Cell Signaling")
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Abstract

Actin binding proteins are of crucial importance for the spatiotemporal regulation of actin cytoskeletal dynamics, thereby mediating a tremendous range of cellular processes. Since their initial discovery more than 30 years ago, the enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family has evolved as one of the most fascinating and versatile family of actin regulating proteins. The proteins directly enhance actin filament assembly, but they also organize higher order actin networks and link kinase signaling pathways to actin filament assembly. Thereby, Ena/VASP proteins regulate dynamic cellular processes ranging from membrane protrusions and trafficking, and cell-cell and cell-matrix adhesions, to the generation of mechanical tension and contractile force. Important insights have been gained into the physiological functions of Ena/VASP proteins in platelets, leukocytes, endothelial cells, smooth muscle cells and cardiomyocytes. In this review, we summarize the unique and redundant functions of Ena/VASP proteins in cardiovascular cells and discuss the underlying molecular mechanisms.
Keywords: Ena/VASP proteins; actin dynamics; receptor trafficking; endothelial barrier function; angiogenesis; leukocyte infiltration and polarization; cardiomyocyte contraction; gap junction assembly; conducted vasodilation; smooth muscle cell relaxation Ena/VASP proteins; actin dynamics; receptor trafficking; endothelial barrier function; angiogenesis; leukocyte infiltration and polarization; cardiomyocyte contraction; gap junction assembly; conducted vasodilation; smooth muscle cell relaxation
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MDPI and ACS Style

Benz, P.M.; Frömel, T.; Laban, H.; Zink, J.; Ulrich, L.; Groneberg, D.; Boon, R.A.; Poley, P.; Renne, T.; de Wit, C.; et al. Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond. Cells 2023, 12, 1740. https://doi.org/10.3390/cells12131740

AMA Style

Benz PM, Frömel T, Laban H, Zink J, Ulrich L, Groneberg D, Boon RA, Poley P, Renne T, de Wit C, et al. Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond. Cells. 2023; 12(13):1740. https://doi.org/10.3390/cells12131740

Chicago/Turabian Style

Benz, Peter M., Timo Frömel, Hebatullah Laban, Joana Zink, Lea Ulrich, Dieter Groneberg, Reinier A. Boon, Philip Poley, Thomas Renne, Cor de Wit, and et al. 2023. "Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond" Cells 12, no. 13: 1740. https://doi.org/10.3390/cells12131740

APA Style

Benz, P. M., Frömel, T., Laban, H., Zink, J., Ulrich, L., Groneberg, D., Boon, R. A., Poley, P., Renne, T., de Wit, C., & Fleming, I. (2023). Cardiovascular Functions of Ena/VASP Proteins: Past, Present and Beyond. Cells, 12(13), 1740. https://doi.org/10.3390/cells12131740

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