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Review

The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth

by 1,*,†, 1,2,†, 2 and 3,*,†
1
Institute of Biochemistry, Department of Biology, ETHZ Zurich, 8093 Zurich, Switzerland
2
Department of Biochemistry, University of Zurich, 8057 Zurich, Switzerland
3
Department of Biological Sciences, University of Bergen, 5020 Bergen, Norway
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Symeon Siniossoglou and Wolfram Antonin
Cells 2022, 11(9), 1456; https://doi.org/10.3390/cells11091456
Received: 31 March 2022 / Revised: 22 April 2022 / Accepted: 23 April 2022 / Published: 25 April 2022
(This article belongs to the Special Issue Lipid and Protein Dynamics at the Nuclear Envelope)
Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear envelope. Constructed from ~500–1000 nucleoporin proteins each, they are among the largest macromolecular assemblies in eukaryotic cells. Thanks to advances in structural analysis approaches, the construction principles and architecture of the NPC have recently been revealed at submolecular resolution. Although the overall structure and inventory of nucleoporins are conserved, NPCs exhibit significant compositional and functional plasticity even within single cells and surprising variability in their assembly pathways. Once assembled, NPCs remain seemingly unexchangeable in post-mitotic cells. There are a number of as yet unresolved questions about how the versatility of NPC assembly and composition is established, how cells monitor the functional state of NPCs or how they could be renewed. Here, we review current progress in our understanding of the key aspects of NPC architecture and lifecycle. View Full-Text
Keywords: nuclear pore complex; nucleoporin; NPC; membrane fusion; Ran; lipids; assembly factor; amphipathic helix; nuclear transport receptor; FG repeats; Brl1; autophagy; ageing; aggregation; neurodegneration nuclear pore complex; nucleoporin; NPC; membrane fusion; Ran; lipids; assembly factor; amphipathic helix; nuclear transport receptor; FG repeats; Brl1; autophagy; ageing; aggregation; neurodegneration
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MDPI and ACS Style

Dultz, E.; Wojtynek, M.; Medalia, O.; Onischenko, E. The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth. Cells 2022, 11, 1456. https://doi.org/10.3390/cells11091456

AMA Style

Dultz E, Wojtynek M, Medalia O, Onischenko E. The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth. Cells. 2022; 11(9):1456. https://doi.org/10.3390/cells11091456

Chicago/Turabian Style

Dultz, Elisa, Matthias Wojtynek, Ohad Medalia, and Evgeny Onischenko. 2022. "The Nuclear Pore Complex: Birth, Life, and Death of a Cellular Behemoth" Cells 11, no. 9: 1456. https://doi.org/10.3390/cells11091456

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