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Cells
Volume 11
Issue 24
10.3390/cells11244074
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Article

Repair of Long Nerve Defects with a New Decellularized Nerve Graft in Rats and in Sheep

by
Estefanía Contreras
1,2,
Sara Traserra
1,2,
Sara Bolívar
1,3,
Joaquim Forés
1,4,
Eduard Jose-Cunilleras
5,
Felix García
5,
Ignacio Delgado-Martínez
1,3,
Sandra Holmgren
6,
Raimund Strehl
6,
Esther Udina
1,3 and
Xavier Navarro
1,3,*
1
Department of Cell Biology, Physiology and Immunology, Institute of Neuroscience, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
2
Integral Service for Laboratory Animals (SIAL), Faculty of Veterinary, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
3
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain
4
Hand and Peripheral Nerve Unit, Hospital Clínic i Provincial, Universitat de Barcelona, 08036 Barcelona, Spain
5
Department of Animal Medicine and Surgery, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
6
VERIGRAFT AB, Arvid Wallgrens Backe 20, 41346 Göteborg, Sweden
*
Author to whom correspondence should be addressed.
Cells 2022, 11(24), 4074; https://doi.org/10.3390/cells11244074
Submission received: 21 October 2022 / Revised: 30 November 2022 / Accepted: 9 December 2022 / Published: 16 December 2022
(This article belongs to the Section Cellular Neuroscience)
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Abstract

Decellularized nerve allografts (DC) are an alternative to autografts (AG) for repairing severe peripheral nerve injuries. We have assessed a new DC provided by VERIGRAFT. The decellularization procedure completely removed cellularity while preserving the extracellular matrix. We first assessed the DC in a 15 mm gap in the sciatic nerve of rats, showing slightly delayed but effective regeneration. Then, we assayed the DC in a 70 mm gap in the peroneal nerve of sheep compared with AG. Evaluation of nerve regeneration and functional recovery was performed by clinical, electrophysiology and ultrasound tests. No significant differences were found in functional recovery between groups of sheep. Histology showed a preserved fascicular structure in the AG while in the DC grafts regenerated axons were grouped in small units. In conclusion, the DC was permissive for axonal regeneration and allowed to repair a 70 mm long gap in the sheep nerve.
Keywords: nerve regeneration; autograft; allograft; decellularization; sheep nerve regeneration; autograft; allograft; decellularization; sheep
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MDPI and ACS Style

Contreras, E.; Traserra, S.; Bolívar, S.; Forés, J.; Jose-Cunilleras, E.; García, F.; Delgado-Martínez, I.; Holmgren, S.; Strehl, R.; Udina, E.; et al. Repair of Long Nerve Defects with a New Decellularized Nerve Graft in Rats and in Sheep. Cells 2022, 11, 4074. https://doi.org/10.3390/cells11244074

AMA Style

Contreras E, Traserra S, Bolívar S, Forés J, Jose-Cunilleras E, García F, Delgado-Martínez I, Holmgren S, Strehl R, Udina E, et al. Repair of Long Nerve Defects with a New Decellularized Nerve Graft in Rats and in Sheep. Cells. 2022; 11(24):4074. https://doi.org/10.3390/cells11244074

Chicago/Turabian Style

Contreras, Estefanía, Sara Traserra, Sara Bolívar, Joaquim Forés, Eduard Jose-Cunilleras, Felix García, Ignacio Delgado-Martínez, Sandra Holmgren, Raimund Strehl, Esther Udina, and et al. 2022. "Repair of Long Nerve Defects with a New Decellularized Nerve Graft in Rats and in Sheep" Cells 11, no. 24: 4074. https://doi.org/10.3390/cells11244074

APA Style

Contreras, E., Traserra, S., Bolívar, S., Forés, J., Jose-Cunilleras, E., García, F., Delgado-Martínez, I., Holmgren, S., Strehl, R., Udina, E., & Navarro, X. (2022). Repair of Long Nerve Defects with a New Decellularized Nerve Graft in Rats and in Sheep. Cells, 11(24), 4074. https://doi.org/10.3390/cells11244074

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