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Colonic Fluid and Electrolyte Transport 2022: An Update

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06510, USA
The John B. Pierce Laboratory, Inc., New Haven, CT 06519, USA
Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
Author to whom correspondence should be addressed.
Academic Editor: Laura Grasa
Cells 2022, 11(10), 1712;
Received: 25 April 2022 / Revised: 16 May 2022 / Accepted: 17 May 2022 / Published: 22 May 2022
Colonic epithelial cells are responsible for maintaining a delicate balance between luminal secretion and the absorption of fluids and ions. This review aims to discuss and update the model of colonic electrolyte secretion and absorption via the cystic fibrosis transmembrane regulator (CFTR), epithelial sodium channel (ENaC), Na-K-Cl cotransporters (NKCC1 and 2), Na-H exchangers (NHE1–4), colonic H,KATPase, and several other key components involved in multi-level transepithelial ion transport. Developments in our understanding of the activity, regulation, localization, and relationships of these ion transporters and their interactions have helped forge a more robust understanding of colonic ion movement that accounts for the colonic epithelium’s role in mucosal pH modulation, the setting of osmotic gradients pivotal for fluid retention and secretion, and cell death regulation. Deviations from homeostatic ion transport cause diarrhea, constipation, and epithelial cell death and contribute to cystic fibrosis, irritable bowel syndrome (IBS), ulcerative colitis, and cancer pathologies. Signal transduction pathways that regulate electrolyte movement and the regulatory relationships between various sensors and transporters (CFTR as a target of CaSR regulation and as a regulator of ENaC and DRA, for example) are imperative aspects of a dynamic and comprehensive model of colonic ion homeostasis. View Full-Text
Keywords: colon physiology; colonic ion transport; CFTR; ENaC; H,KATPase; NHE; NKCC; IBS colon physiology; colonic ion transport; CFTR; ENaC; H,KATPase; NHE; NKCC; IBS
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MDPI and ACS Style

Negussie, A.B.; Dell, A.C.; Davis, B.A.; Geibel, J.P. Colonic Fluid and Electrolyte Transport 2022: An Update. Cells 2022, 11, 1712.

AMA Style

Negussie AB, Dell AC, Davis BA, Geibel JP. Colonic Fluid and Electrolyte Transport 2022: An Update. Cells. 2022; 11(10):1712.

Chicago/Turabian Style

Negussie, Abel B., Annika C. Dell, Bruce A. Davis, and John P. Geibel. 2022. "Colonic Fluid and Electrolyte Transport 2022: An Update" Cells 11, no. 10: 1712.

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