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10.3390/cells10082111
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Brief Report

Expansion of Myeloid Derived Suppressor Cells Contributes to Platelet Activation by L-Arginine Deprivation during SARS-CoV-2 Infection

by
Alessandra Sacchi
1,*,
Germana Grassi
1,
Stefania Notari
1,
Simona Gili
1,
Veronica Bordoni
1,
Eleonora Tartaglia
1,
Rita Casetti
1,
Eleonora Cimini
1,
Davide Mariotti
1,
Gabriele Garotto
2,
Alessia Beccacece
2,
Luisa Marchioni
2,
Michele Bibas
2,
Emanuele Nicastri
2,
Giuseppe Ippolito
3 and
Chiara Agrati
1
1
Department of Epidemiology, Pre-Clinical Research and Advanced Diagnostic, National Institute for Infectious Diseases “Lazzaro Spallanzani”-IRCCS, Via Portuense, 292-00149 Rome, Italy
2
Clinical Department, National Institute for Infectious Diseases “Lazzaro Spallanzani”-IRCCS, Via Portuense, 292-00149 Rome, Italy
3
National Institute for Infectious Diseases “Lazzaro Spallanzani”-IRCCS, Via Portuense, 292-00149 Rome, Italy
*
Author to whom correspondence should be addressed.
Cells 2021, 10(8), 2111; https://doi.org/10.3390/cells10082111
Submission received: 14 July 2021 / Revised: 10 August 2021 / Accepted: 12 August 2021 / Published: 17 August 2021
(This article belongs to the Collection Cellular Immunology and COVID-19)
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Abstract

Massive platelet activation and thrombotic events characterize severe COVID-19, highlighting their critical role in SARS-CoV-2-induced immunopathology. Since there is a well-described expansion of myeloid-derived suppressor cells (MDSC) in severe COVID-19, we evaluated their possible role in platelet activation during SARS-CoV-2 infection. During COVID-19, a lower plasmatic L-arginine level was observed compared to healthy donors, which correlated with MDSC frequency. Additionally, activated GPIIb/IIIa complex (PAC-1) expression was higher on platelets from severe COVID-19 patients compared to healthy controls and inversely correlated with L-arginine plasmatic concentration. Notably, MDSC were able to induce PAC-1 expression in vitro by reducing L-arginine concentration, indicating a direct role of PMN-MDSC in platelet activation. Accordingly, we found a positive correlation between ex vivo platelet PAC-1 expression and PMN-MDSC frequency. Overall, our data demonstrate the involvement of PMN-MDSC in triggering platelet activation during COVID-19, highlighting a novel role of MDSC in driving COVID-19 pathogenesis.
Keywords: COVID-19; MDSC; platelet; L-Arginine COVID-19; MDSC; platelet; L-Arginine
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MDPI and ACS Style

Sacchi, A.; Grassi, G.; Notari, S.; Gili, S.; Bordoni, V.; Tartaglia, E.; Casetti, R.; Cimini, E.; Mariotti, D.; Garotto, G.; et al. Expansion of Myeloid Derived Suppressor Cells Contributes to Platelet Activation by L-Arginine Deprivation during SARS-CoV-2 Infection. Cells 2021, 10, 2111. https://doi.org/10.3390/cells10082111

AMA Style

Sacchi A, Grassi G, Notari S, Gili S, Bordoni V, Tartaglia E, Casetti R, Cimini E, Mariotti D, Garotto G, et al. Expansion of Myeloid Derived Suppressor Cells Contributes to Platelet Activation by L-Arginine Deprivation during SARS-CoV-2 Infection. Cells. 2021; 10(8):2111. https://doi.org/10.3390/cells10082111

Chicago/Turabian Style

Sacchi, Alessandra, Germana Grassi, Stefania Notari, Simona Gili, Veronica Bordoni, Eleonora Tartaglia, Rita Casetti, Eleonora Cimini, Davide Mariotti, Gabriele Garotto, and et al. 2021. "Expansion of Myeloid Derived Suppressor Cells Contributes to Platelet Activation by L-Arginine Deprivation during SARS-CoV-2 Infection" Cells 10, no. 8: 2111. https://doi.org/10.3390/cells10082111

APA Style

Sacchi, A., Grassi, G., Notari, S., Gili, S., Bordoni, V., Tartaglia, E., Casetti, R., Cimini, E., Mariotti, D., Garotto, G., Beccacece, A., Marchioni, L., Bibas, M., Nicastri, E., Ippolito, G., & Agrati, C. (2021). Expansion of Myeloid Derived Suppressor Cells Contributes to Platelet Activation by L-Arginine Deprivation during SARS-CoV-2 Infection. Cells, 10(8), 2111. https://doi.org/10.3390/cells10082111

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