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Spinal Cord Repair: From Cells and Tissue Engineering to Extracellular Vesicles

Plasticity of the Injured Spinal Cord

EA3830 GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université, UNIROUEN, 76000 Rouen, France
Academic Editor: Hakan Aldskogius
Cells 2021, 10(8), 1886;
Received: 1 July 2021 / Revised: 21 July 2021 / Accepted: 23 July 2021 / Published: 26 July 2021
Complete spinal cord injury (SCI) leads to permanent motor, sensitive and sensory deficits. In humans, there is currently no therapy to promote recovery and the only available treatments include surgical intervention to prevent further damage and symptomatic relief of pain and infections in the acute and chronic phases, respectively. Basically, the spinal cord is classically viewed as a nonregenerative tissue with limited plasticity. Thereby the establishment of the “glial” scar which appears within the SCI is mainly described as a hermetic barrier for axon regeneration. However, recent discoveries have shed new light on the intrinsic functional plasticity and endogenous recovery potential of the spinal cord. In this review, we will address the different aspects that the spinal cord plasticity can take on. Indeed, different experimental paradigms have demonstrated that axonal regrowth can occur even after complete SCI. Moreover, recent articles have demonstrated too that the “glial” scar is in fact composed of several cellular populations and that each of them exerts specific roles after SCI. These recent discoveries underline the underestimation of the plasticity of the spinal cord at cellular and molecular levels. Finally, we will address the modulation of this endogenous spinal cord plasticity and the perspectives of future therapeutic opportunities which can be offered by modulating the injured spinal cord microenvironment. View Full-Text
Keywords: spinal cord injury; plasticity; stem cells; transplantation; repair; rehabilitation; glial scar spinal cord injury; plasticity; stem cells; transplantation; repair; rehabilitation; glial scar
MDPI and ACS Style

Guérout, N. Plasticity of the Injured Spinal Cord. Cells 2021, 10, 1886.

AMA Style

Guérout N. Plasticity of the Injured Spinal Cord. Cells. 2021; 10(8):1886.

Chicago/Turabian Style

Guérout, Nicolas. 2021. "Plasticity of the Injured Spinal Cord" Cells 10, no. 8: 1886.

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