Regulation of Store-Operated Ca2+ Entry by SARAF
Technion Integrated Cancer Center, Department of Biochemistry, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 31096, Israel
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Author to whom correspondence should be addressed.
Academic Editor: Isabella Derler
Cells 2021, 10(8), 1887; https://doi.org/10.3390/cells10081887
Received: 30 June 2021
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Revised: 19 July 2021
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Accepted: 22 July 2021
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Published: 26 July 2021
(This article belongs to the Collection STIM and Orai Communication in Health and Disease)
Calcium (Ca2+) signaling plays a dichotomous role in cellular biology, controlling cell survival and proliferation on the one hand and cellular toxicity and cell death on the other. Store-operated Ca2+ entry (SOCE) by CRAC channels represents a major pathway for Ca2+ entry in non-excitable cells. The CRAC channel has two key components, the endoplasmic reticulum Ca2+ sensor stromal interaction molecule (STIM) and the plasma-membrane Ca2+ channel Orai. Physical coupling between STIM and Orai opens the CRAC channel and the resulting Ca2+ flux is regulated by a negative feedback mechanism of slow Ca2+ dependent inactivation (SCDI). The identification of the SOCE-associated regulatory factor (SARAF) and investigations of its role in SCDI have led to new functional and molecular insights into how SOCE is controlled. In this review, we provide an overview of the functional and molecular mechanisms underlying SCDI and discuss how the interaction between SARAF, STIM1, and Orai1 shapes Ca2+ signaling in cells.
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Keywords:
store operated calcium entry (SOCE); STIM1; SARAF; Orai1; CRAC channel; slow calcium dependent inactivation (CDI)
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MDPI and ACS Style
Dagan, I.; Palty, R. Regulation of Store-Operated Ca2+ Entry by SARAF. Cells 2021, 10, 1887. https://doi.org/10.3390/cells10081887
AMA Style
Dagan I, Palty R. Regulation of Store-Operated Ca2+ Entry by SARAF. Cells. 2021; 10(8):1887. https://doi.org/10.3390/cells10081887
Chicago/Turabian StyleDagan, Inbal, and Raz Palty. 2021. "Regulation of Store-Operated Ca2+ Entry by SARAF" Cells 10, no. 8: 1887. https://doi.org/10.3390/cells10081887
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