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Review

A Review on Lactoferrin and Central Nervous System Diseases

by and *
College of Life and Health Sciences, Northeastern University, No. 195, Chuangxin Road, Hunnan District, Shenyang 110169, China
*
Author to whom correspondence should be addressed.
Academic Editor: Dominique Debanne
Cells 2021, 10(7), 1810; https://doi.org/10.3390/cells10071810
Received: 8 June 2021 / Revised: 8 July 2021 / Accepted: 15 July 2021 / Published: 17 July 2021
(This article belongs to the Collection Feature Papers in Cells of the Nervous System)
Central nervous system (CNS) diseases are currently one of the major health issues around the world. Most CNS disorders are characterized by high oxidative stress levels and intense inflammatory responses in affected tissues. Lactoferrin (Lf), a multifunctional iron-binding glycoprotein, plays a significant role in anti-inflammatory, antibacterial, antiviral, reactive oxygen species (ROS) modulator, antitumor immunity, and anti-apoptotic processes. Previous studies have shown that Lf is abnormally expressed in a variety of neurological diseases, especially neurodegenerative diseases. Recently, the promotion of neurodevelopment and neuroprotection by Lf has attracted widespread attention, and Lf could be exploited both as an active therapeutic agent and drug nanocarrier. However, our understanding of the roles of Lf proteins in the initiation or progression of CNS diseases is limited, especially the roles of Lf in regulating neurogenesis. This review highlights recent advances in the understanding of the major pharmacological effects of Lf in CNS diseases, including neurodegenerative diseases, cerebrovascular disease, developmental delays in children, and brain tumors. View Full-Text
Keywords: lactoferrin; iron homeostasis; central nervous system diseases; neurodevelopment; neuroprotection lactoferrin; iron homeostasis; central nervous system diseases; neurodevelopment; neuroprotection
MDPI and ACS Style

Li, Y.-Q.; Guo, C. A Review on Lactoferrin and Central Nervous System Diseases. Cells 2021, 10, 1810. https://doi.org/10.3390/cells10071810

AMA Style

Li Y-Q, Guo C. A Review on Lactoferrin and Central Nervous System Diseases. Cells. 2021; 10(7):1810. https://doi.org/10.3390/cells10071810

Chicago/Turabian Style

Li, Yu-Qi, and Chuang Guo. 2021. "A Review on Lactoferrin and Central Nervous System Diseases" Cells 10, no. 7: 1810. https://doi.org/10.3390/cells10071810

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