Next Article in Journal
Indonesia-Based Study of the Clinical and Cost-Saving Benefits of Subcutaneous Allergen Immunotherapy for Children with Allergic Rhinitis in Private Practice
Next Article in Special Issue
Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1
Previous Article in Journal
Transcriptomic Hallmarks of Ischemia-Reperfusion Injury
Previous Article in Special Issue
A Review on Lactoferrin and Central Nervous System Diseases
Article

Transcriptomic Profile Reveals Deregulation of Hearing-Loss Related Genes in Vestibular Schwannoma Cells Following Electromagnetic Field Exposure

1
Department of Pharmacological and Biomolecular Sciences, Università Degli Studi di Milano, Via G. Balzaretti 9, 20133 Milan, Italy
2
Blond McIndoe Laboratories, Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9NQ, UK
3
Department of Plastic Surgery & Burns, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Center, Manchester M13 9NQ, UK
4
Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Dominique Debanne
Cells 2021, 10(7), 1840; https://doi.org/10.3390/cells10071840
Received: 10 June 2021 / Revised: 16 July 2021 / Accepted: 18 July 2021 / Published: 20 July 2021
(This article belongs to the Collection Feature Papers in Cells of the Nervous System)
Hearing loss (HL) is the most common sensory disorder in the world population. One common cause of HL is the presence of vestibular schwannoma (VS), a benign tumor of the VIII cranial nerve, arising from Schwann cell (SC) transformation. In the last decade, the increasing incidence of VS has been correlated to electromagnetic field (EMF) exposure, which might be considered a pathogenic cause of VS development and HL. Here, we explore the molecular mechanisms underlying the biologic changes of human SCs and/or their oncogenic transformation following EMF exposure. Through NGS technology and RNA-Seq transcriptomic analysis, we investigated the genomic profile and the differential display of HL-related genes after chronic EMF. We found that chronic EMF exposure modified the cell proliferation, in parallel with intracellular signaling and metabolic pathways changes, mostly related to translation and mitochondrial activities. Importantly, the expression of HL-related genes such as NEFL, TPRN, OTOGL, GJB2, and REST appeared to be deregulated in chronic EMF exposure. In conclusion, we suggest that, at a preclinical stage, EMF exposure might promote the transformation of VS cells and contribute to HL. View Full-Text
Keywords: Schwann cell; NF2; GJB2; hearing loss; NEFL; TPRN; OTOGL; REST Schwann cell; NF2; GJB2; hearing loss; NEFL; TPRN; OTOGL; REST
Show Figures

Figure 1

MDPI and ACS Style

Colciago, A.; Audano, M.; Bonalume, V.; Melfi, V.; Mohamed, T.; Reid, A.J.; Faroni, A.; Greer, P.A.; Mitro, N.; Magnaghi, V. Transcriptomic Profile Reveals Deregulation of Hearing-Loss Related Genes in Vestibular Schwannoma Cells Following Electromagnetic Field Exposure. Cells 2021, 10, 1840. https://doi.org/10.3390/cells10071840

AMA Style

Colciago A, Audano M, Bonalume V, Melfi V, Mohamed T, Reid AJ, Faroni A, Greer PA, Mitro N, Magnaghi V. Transcriptomic Profile Reveals Deregulation of Hearing-Loss Related Genes in Vestibular Schwannoma Cells Following Electromagnetic Field Exposure. Cells. 2021; 10(7):1840. https://doi.org/10.3390/cells10071840

Chicago/Turabian Style

Colciago, Alessandra, Matteo Audano, Veronica Bonalume, Valentina Melfi, Tasnim Mohamed, Adam J. Reid, Alessandro Faroni, Peter A. Greer, Nico Mitro, and Valerio Magnaghi. 2021. "Transcriptomic Profile Reveals Deregulation of Hearing-Loss Related Genes in Vestibular Schwannoma Cells Following Electromagnetic Field Exposure" Cells 10, no. 7: 1840. https://doi.org/10.3390/cells10071840

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop