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The Role of Coagulation and Complement Factors for Mast Cell Activation in the Pathogenesis of Chronic Spontaneous Urticaria

1
Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan
2
Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan
3
Department of Dermatology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima 730-8518, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Alessandro Poggi
Cells 2021, 10(7), 1759; https://doi.org/10.3390/cells10071759
Received: 31 May 2021 / Revised: 9 July 2021 / Accepted: 9 July 2021 / Published: 12 July 2021
(This article belongs to the Special Issue Mast Cells in Health and Diseases)
Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by an almost daily recurrence of wheal and flare with itch for more than 6 weeks, in association with the release of stored inflammatory mediators, such as histamine, from skin mast cells and/or peripheral basophils. The involvement of the extrinsic coagulation cascade triggered by tissue factor (TF) and complement factors, such as C3a and C5a, has been implied in the pathogenesis of CSU. However, it has been unclear how the TF-triggered coagulation pathway and complement factors induce the activation of skin mast cells and peripheral basophils in patients with CSU. In this review, we focus on the role of vascular endothelial cells, leukocytes, extrinsic coagulation factors and complement components on TF-induced activation of skin mast cells and peripheral basophils followed by the edema formation clinically recognized as urticaria. These findings suggest that medications targeting activated coagulation factors and/or complement components may represent new and effective treatments for patients with severe and refractory CSU. View Full-Text
Keywords: chronic spontaneous urticaria (CSU); mast cells; leukocytes; coagulation factors; endothelial cells; complement components; protease activated receptor (PAR); activated complement factor 5 (C5a) chronic spontaneous urticaria (CSU); mast cells; leukocytes; coagulation factors; endothelial cells; complement components; protease activated receptor (PAR); activated complement factor 5 (C5a)
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MDPI and ACS Style

Yanase, Y.; Takahagi, S.; Ozawa, K.; Hide, M. The Role of Coagulation and Complement Factors for Mast Cell Activation in the Pathogenesis of Chronic Spontaneous Urticaria. Cells 2021, 10, 1759. https://doi.org/10.3390/cells10071759

AMA Style

Yanase Y, Takahagi S, Ozawa K, Hide M. The Role of Coagulation and Complement Factors for Mast Cell Activation in the Pathogenesis of Chronic Spontaneous Urticaria. Cells. 2021; 10(7):1759. https://doi.org/10.3390/cells10071759

Chicago/Turabian Style

Yanase, Yuhki, Shunsuke Takahagi, Koichiro Ozawa, and Michihiro Hide. 2021. "The Role of Coagulation and Complement Factors for Mast Cell Activation in the Pathogenesis of Chronic Spontaneous Urticaria" Cells 10, no. 7: 1759. https://doi.org/10.3390/cells10071759

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