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Chromothripsis—Explosion in Genetic Science

Department of Intracellular Signaling and Transport, Institute of Cytology, Russian Academy of Sciences, Tikhoretskay Ave 4, 194064 St. Petersburg, Russia
Author to whom correspondence should be addressed.
Academic Editor: Eric P. Hoffman
Cells 2021, 10(5), 1102;
Received: 1 April 2021 / Revised: 27 April 2021 / Accepted: 1 May 2021 / Published: 4 May 2021
Chromothripsis has been defined as complex patterns of alternating genes copy number changes (normal, gain or loss) along the length of a chromosome or chromosome segment (International System for Human Cytogenomic Nomenclature 2020). The phenomenon of chromothripsis was discovered in 2011 and changed the concept of genome variability, mechanisms of oncogenic transformation, and hereditary diseases. This review describes the phenomenon of chromothripsis, its prevalence in genomes, the mechanisms underlying this phenomenon, and methods of its detection. Due to the fact that most often the phenomenon of chromothripsis occurs in cancer cells, in this review, we will separately discuss the issue of the contribution of chromothripsis to the process of oncogenesis. View Full-Text
Keywords: chromothripsis; chromosomal instability; micronuclei; cancer; transformation chromothripsis; chromosomal instability; micronuclei; cancer; transformation
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MDPI and ACS Style

Shorokhova, M.; Nikolsky, N.; Grinchuk, T. Chromothripsis—Explosion in Genetic Science. Cells 2021, 10, 1102.

AMA Style

Shorokhova M, Nikolsky N, Grinchuk T. Chromothripsis—Explosion in Genetic Science. Cells. 2021; 10(5):1102.

Chicago/Turabian Style

Shorokhova, Mariia; Nikolsky, Nikolay; Grinchuk, Tatiana. 2021. "Chromothripsis—Explosion in Genetic Science" Cells 10, no. 5: 1102.

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