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Review

Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma

1
Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, 171 64 Stockholm, Sweden
2
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, Australia
3
Department of Optometry & Vision Sciences, The University of Melbourne, Melbourne, VIC 3053, Australia
4
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore
5
Duke-NUS Medical School, Singapore 169857, Singapore
*
Author to whom correspondence should be addressed.
Academic Editors: Stanislav I. Tomarev and Ben Mead
Cells 2021, 10(2), 295; https://doi.org/10.3390/cells10020295
Received: 17 December 2020 / Revised: 15 January 2021 / Accepted: 28 January 2021 / Published: 1 February 2021
Glaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive dysfunction and death of retinal ganglion cells occurs, eliminating transfer of visual information to the brain. Currently, the only available therapies target the lowering of intraocular pressure, but many patients continue to lose vision. Emerging pre-clinical and clinical evidence suggests that metabolic deficiencies and defects may play an important role in glaucoma pathophysiology. While pre-clinical studies in animal models have begun to mechanistically uncover these metabolic changes, some existing clinical evidence already points to potential benefits in maintaining metabolic fitness. Modifying diet and exercise can be implemented by patients as an adjunct to intraocular pressure lowering, which may be of therapeutic benefit to retinal ganglion cells in glaucoma. View Full-Text
Keywords: glaucoma; optic nerve; retinal ganglion cells; diet; exercise; NAD; pyruvate; lactate; recovery; ketogenesis glaucoma; optic nerve; retinal ganglion cells; diet; exercise; NAD; pyruvate; lactate; recovery; ketogenesis
MDPI and ACS Style

Tribble, J.R.; Hui, F.; Jöe, M.; Bell, K.; Chrysostomou, V.; Crowston, J.G.; Williams, P.A. Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma. Cells 2021, 10, 295. https://doi.org/10.3390/cells10020295

AMA Style

Tribble JR, Hui F, Jöe M, Bell K, Chrysostomou V, Crowston JG, Williams PA. Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma. Cells. 2021; 10(2):295. https://doi.org/10.3390/cells10020295

Chicago/Turabian Style

Tribble, James R., Flora Hui, Melissa Jöe, Katharina Bell, Vicki Chrysostomou, Jonathan G. Crowston, and Pete A. Williams. 2021. "Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma" Cells 10, no. 2: 295. https://doi.org/10.3390/cells10020295

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