Astrocytic Regulation of Neural Circuits Underlying Behaviors
1
Convergence Research Advanced Centre for Olfaction, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea
2
Department of Brain and Cognitive Sciences, DGIST, Daegu 42988, Korea
3
Korea Brain Research Institute (KBRI), Daegu 41062, Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editor: Mariagrazia Grilli
Cells 2021, 10(2), 296; https://doi.org/10.3390/cells10020296
Received: 29 December 2020
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Revised: 23 January 2021
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Accepted: 29 January 2021
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Published: 1 February 2021
(This article belongs to the Special Issue The Function of Glial Cells in the Neuroinflammatory and Neuroimmunological Responses)
Astrocytes, characterized by a satellite-like morphology, are the most abundant type of glia in the central nervous system. Their main functions have been thought to be limited to providing homeostatic support for neurons, but recent studies have revealed that astrocytes actually actively interact with local neural circuits and play a crucial role in information processing and generating physiological and behavioral responses. Here, we review the emerging roles of astrocytes in many brain regions, particularly by focusing on intracellular changes in astrocytes and their interactions with neurons at the molecular and neural circuit levels.
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Keywords:
astrocyte; neural circuit; behavior; GFAP; chemogenetics; optogenetics
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MDPI and ACS Style
Hwang, S.-N.; Lee, J.S.; Seo, K.; Lee, H. Astrocytic Regulation of Neural Circuits Underlying Behaviors. Cells 2021, 10, 296. https://doi.org/10.3390/cells10020296
AMA Style
Hwang S-N, Lee JS, Seo K, Lee H. Astrocytic Regulation of Neural Circuits Underlying Behaviors. Cells. 2021; 10(2):296. https://doi.org/10.3390/cells10020296
Chicago/Turabian StyleHwang, Sun-Nyoung, Jae S. Lee, Kain Seo, and Hyosang Lee. 2021. "Astrocytic Regulation of Neural Circuits Underlying Behaviors" Cells 10, no. 2: 296. https://doi.org/10.3390/cells10020296
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